东北农业大学导师简介系统

姓名：王家俊

性别：男

出生年月：1989-10-20

职称：副教授

办公电话：15124530820

工作单位：东北农业大学动物科学技术学院

E-mail：wjj1989@neau.edu.cn

开设研究生课程情况

课程编号

课程名称

课程级别

学时

近五年主持科研项目概况

(1) 国家自然科学基金委员会, 青年科学基金项目, 32002215, 高稳定脂酰肽的分子设计、纳米组装体构建及猪肠道内抗菌效力研究, 2021-01-01 至 2023-12-31，24万元，结题，主持

(2) 黑龙江省人社厅, 黑龙江省博士后面上项目, LBH-Z21003, 脂酰化富脯氨酸肽分子的全新设计、纳米组装体构建及其体内应用效果研究, 2021-12 至 2024-12, 10万元, 在研, 主持

(3) 东北农业大学, “东农学者”学术骨干项目（人才引进）, 19YJXG05, 疏水性氨基酸尾端锚定结构对抗菌肽生物学活性的影响, 2019-09 至 2024-09, 30万元, 在研，主持

(4) 中国博士后基金委, 中国博士后面上项目, 2021M690576, 抗酶解型Trp富集肽的分子设计、构效关系及抗菌机制研究, 2021-06 至 2024-06, 8万元, 在研，主持

(5) 黑龙江省科技厅, 黑龙江省自然科学基金优秀青年项目, YQ2020C009, 抗酶解β-折叠肽的全新设计及其对腹泻断奶仔猪肠道健康的影响, 2020-07 至 2023-07, 10万元, 结题，主持

(6) 黑龙江省人社厅，黑龙江省博士后特别资助项目，LBH-TZ2305，纳米靶向捕获肽分子骨架设计及其对腹泻仔猪肠屏障功能影响的研究，2023年12至今，30万元，在研，主持

近五年项目获奖概况

(1) 2020年度帝斯曼缤纷科技奖——动物营养科学青年学者奖-优胜奖

(2) 2020年度黑龙江省优青

(3) 2021年度黑龙江省研究生导学思政团队（导师）——非粮型饲料资源研发研究生导学思政团队

(4) 2022年度颐和青年奖——新锐奖

(5) 2023年中国畜牧兽医学会动物营养学分会第六届青年学者讲坛——优秀报告

(6) 2023年饲料创新研究生论坛—优胜奖（指导教师）

近五年代表性著作、论文

1. 第一作者或通讯作者

1. Gao, Nan; Wang, Jiajun*; Fang, Chunyang; Bai, Pengfei; Sun, Yu; Wu, Wanpeng; Shan, Anshan*. Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity. DRUG RESISTANCE UPDATES, 2023, 72: 10103 (IF₂₀₂₂=24.3, 中科院分区₂₀₂₃一区Top)

2. Su, Yunzhe; Sun, Taotao; Gao, Junhan; Zhang, Chenxu; Liu, Xuesheng; Bi, Chongpeng; Wang, Jiajun*; Shan, Anshan*. Anti-Proteolytic Peptide R7I Protects the Intestinal Barrier and Alleviates Fatty Acid Malabsorption in Salmonella Typhimurium-Infected Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24:22 (IF₂₀₂₂=5.6, 中科院分区₂₀₂₃二区)

3. Yang, Zhanyi; He, Shiqi; Wei, Yingxin; Li, Xuefeng; Shan, Anshan*; Wang, Jiajun*, Antimicrobial peptides in combination with citronellal efficiently kills multidrug resistance bacteria. PHYTOMEDICINE, 2023, 120: 155070 (IF₂₀₂₂=7.9, 中科院分区₂₀₂₃一区Top)

4. He, Shiqi; Yang, Zhanyi; Li, Xuefeng; Wu, Hua; Zhang, Licong; Shan, Anahsn*; Wang, Jiajun*, Boosting Stability and Therapeutic Potential of Proteolysis-Resistant Antimicrobial Peptides by End-Tagging β-Naphthylalanine. Acta Biomaterialia, 2023, 164:175-194. (IF₂₀₂₂=9.7, 中科院分区₂₀₂₃一区Top)

5. Yu, Weikang; Sun, Yu; Li, Wenyu; Guo, Xu.; Liu, Xuesheng; Wu, Wanpeng; Yu, Wanqi; Wang, Jiajun*; Shan, Anshan*, Self-Assembly of Antimicrobial Peptide-Based Micelles Breaks the Limitation of Trypsin. ACS Applied Materials & Interfaces, 2022,15(1):494-510 ( IF₂₀₂₁=10.383, 中科院分区₂₀₂₂二区Top)

6. Sun, Taotao; Liu, Xuesheng; Su, Yunzhe; Wang, Zihang; Cheng, Baojing; Dong, Na; Wang, Jiajun*; Shan, Anshan*. The Efficacy of Anti-Proteolytic Peptide R7I in Intestinal Inflammation, Function, Microbiota, and Metabolites by Multi-Omics Analysis in Murine Bacterial Enteritis. Bioengineering & Translational Medicine. 2023, 8 (2). (IF₂₀₂₁=10.684, 中科院分区₂₀₂₂二区)

7. He, Shiqi; Yang, Zhanyi; Li, Xuefeng; Wu, Hua; Zhang, Licong; Wang, Jiajun*; Shan, Anshan*, Optimized Proteolytic Resistance Motif (DabW)-Based U1-2WD: A Membrane-Induced Self-Aggregating Peptide to Trigger Bacterial Agglutination and Death. Acta Biomaterialia, 2022, 153, 540-556. (IF₂₀₂₁=10.633, 中科院分区₂₀₂₂一区Top)

8. Wang, Jiajun*; Li, Wenyu; KHosravi-Darani, Kianoush; Kim, In Ho, Editorial: The Development and Utilization of Novel Antibiotic Alternatives. Frontiers in Microbiology, 2022, 13:1008850. (IF₂₀₂₁=6.064, 中科院分区₂₀₂₂二区Top)

9. Li, Qiuke; Li, Jinze; Yu, Weikang; Wang, Zhihua; Li, Jiawei, Feng, Xingjun; Wang, Jiajun*; Shan, Anshan*, De Novo Design of A pH-Triggered Self-Assembled β-Hairpin Nanopeptide with the Dual Biological Functions for Antibacterial and Entrapment. Journal of Nanobiotechnology, 2021, 19:183. (IF₂₀₂₀=10.435, 中科院分区₂₀₂₁一区Top)

10. Yu, Weikang^#; Wang, Jiajun^#; Wang, Zihang; Li, Lingxue; Li, Wenyu; Song, Jing; Zhang, Shanshan; Shan, Anshan*, PEGylation of the Antimicrobial Peptide PG-1: A Link between Propensity for Nanostructuring and Capacity of the Antitrypsin Hydrolytic Ability[J]. Journal of Medicinal Chemistry, 2021, 64 (14): 10469-10481. (IF₂₀₂₀=7.446, 中科院分区(升级)₂₀₂₁一区Top)

11. 于伟康,张珊珊,杨占一,王家俊*,单安山*.超分子多肽自组装在生物医学中的应用[J].生物工程学报, 2021, 37 (07):2240-2255.

12. Yang, Yang; Wang, Chenxi; Gao, Nan; Lyu, Yinfeng; Zhang, Licong; Zhang, Sujiang; Wang, Jiajun*; Shan, Anshan*, A Novel Dual-Targeted α-Helical Peptide with Potent Antifungal Activity against Fluconazole-Resistant Candida Albicans Clinical Isolates[J]. Frontiers in Microbiology, 2020, 11 (548620). (IF₂₀₁₉=4.236,中科院分区(升级)₂₀₂₀二区Top)

13. He, Shiqi; Yang, Zhanyi; Yu, Weikang; Li, Jiawei; Li, Zhongyu; Wang, Jiajun*; Shan, Anshan*, Systematically Studying the Optimal Amino Acid Distribution Patterns of the Amphiphilic Structure by Using the Ultrashort Amphiphiles[J]. Frontiers in Microbiology, 2020, 11:569118. (IF₂₀₁₉=4.236,中科院分区(升级)₂₀₂₀二区Top)

14. Wang, Jiajun; Dou, Xiujing; Song, Jing; Lyu, Yinfeng; Zhu, Xin; Xu, Lin; Li, Weizhong; Shan, Anshan*, Antimicrobial Peptides: Promising Alternatives in the Post Feeding Antibiotic era[J], Medicinal Research Reviews, 2019, 39 (3): 831-859. (IF₂₀₁₈=9.791, 中科院分区(升级)₂₀₁₉一区Top, 热点文章)

15. Song, Jing^#; Wang, Jiajun^#; Zhan, Na; Sun, Taotao; Yu, Weikang; Zhang, Licong; Shan, Anshan*; Zhang, Aizhong, Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging, ACS Applied Materials & Interfaces, 2019, 11 (47): 43820-43834. (IF₂₀₁₈=8.456, 中科院分区(升级)₂₀₁₉一区Top)

16. Wang, Jiajun#; Song, Jing#; Yang, Zhanyi; He, Shiqi; Yang, Yi; Feng, Xingjun; Dou, Xiujing; Shan, Anshan*, Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria[J], Journal of Medicinal Chemistry, 2019, 62 (5): 2286-2304. (IF₂₀₁₈=6.054, 中科院分区(升级)₂₀₁₉一区Top)

17. Chou, Shuli^#; Wang, Jiajun^#; Shang, Lu; Akhtar Muhammad Usman; Wang, Zhihua; Shi, Baoming; Feng, Xingjun; Shan, Anshan*, Short, Symmetric-Helical Peptides Have Narrow-Spectrum Activity with Low Resistance Potential and High Selectivity[J]. Biomaterials Science, 2019, 7 (6): 2394-2409.(IF₂₀₁₈=5.251, 中科院分区(升级)₂₀₁₉二区)

18. Wang, Jiajun^#; Chou, Shuli^#; Yang, Zhanyi; Yang, Yang; Wang, Zhihua; Song, Jing; Dou, Xiujing; Shan, Anshan*, Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides[J]. Journal of Medicinal Chemistry, 2018, 61 (9): 3889-3907. (IF₂₀₁₇=6.253, 中科院分区(升级)₂₀₁₈一区)

19. Wang, Jiajun; Chou, Shuli; Xu, Lin; Zhu, Xin; Dong, Na; Shan, Anshan*; Chen Zhihui, High Specific Selectivity and Membrane-Active Mechanism of the Synthetic Centrosymmetric Alpha-Helical Peptides with Gly-Gly Pairs[J]. Scientific Reports, 2015, 5: 15963. (IF₂₀₁₄=5.578, 中科院分区₂₀₁₅二区)

2. 非第一作者或通讯作者

1. Yang, Zhanyi; Wei, Yingxin; Wu, Wanpeng; Zhang, Licong; Wang, Jiajun; Shan, Anshan*, Characterization of Simplified Nonapeptides with Broad-Spectrum Antimicrobial Activities as Potential Food Preservatives, and Their Antibacterial Mechanism. Food & Function, 2023, 14 (7), 3139-3154. (IF₂₀₂₁=6.317, 中科院分区₂₀₂₂一区Top)

2. Zhan, Na; Zhang, Licong; Yang, Hong; Zheng, Yanlan; Wei, Xinke; Wang, Jiajun; Shan, Anshan*, Design and Heterologous Expression of A Novel Dimeric LL37 Variant in Pichia Pastoris[J]. Microbial Cell Factories, 2021, 20 (1): 13. (IF₂₀₂₀=5.328,中科院分区₂₀₂₁二区)

3. 张珊珊，宋静，王家俊，单安山*.细菌生物膜的形成及抗菌肽抗生物膜活性的研究进展.动物营养学报, 2021

4. Wang, Chensi; Shao, Changxuan; Fang, Yuxin; Wang, Jiajun; Dong, Na; Shan, Anshan*, Binding Loop of Sunflower Trypsin Inhibitor 1 Serves as A Design Motif for Proteolysis-Resistant Antimicrobial Peptides. Acta Biomaterialia.2021. 124: 254-269. (IF₂₀₂₀=8.947,中科院分区₂₀₂₁一区Top)

5. Li, Jiawei; Shang, Lu; Lan, Jing; Chou, Shuli; Feng, Xingjun; Shi, Baoming; Wang, Jiajun; Lyu, Yinfeng; Shan, Anshan*, Targeted and Intracellular Antibacterial Activity against S. galactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides[J]. ACS Applied Materials & Interfaces, 2020, 12 (40): 44459-44474. (IF₂₀₁₉=8.758,中科院分区₂₀₂₀一区Top)

6. Xu, Lin; Shao, Changxuan; Li, Guoyu; Shan, Anshan; Chou, Shuli; Wang, Jiajun; Ma, Qingquan; Dong, Na, Conversion of Broad-Spectrum Antimicrobial Peptides into Species-Specific Antimicrobials Capable of Precisely Targeting Pathogenic Bacteria[J]. Scientific Reports, 2020, 10 (1): 944. (IF₂₀₁₉=3.998,中科院分区₂₀₂₀三区)

7. Yang, Zhanyi; He, Shiqi; Wang, Jiajun; Yang, Yi; Zhang, Licong; Li, Yanbing; Shan, Anshan*, Rational Design of Short Peptide Variants by Using Kunitzin-RE, An Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens[J]. Journal of Medicinal Chemistry, 2019, 62 (9): 4586-4605. (IF₂₀₁₈=6.054, 中科院分区(升级)₂₀₁₉一区Top)

8. Dou, Xiujing; Zhu, Xin; Wang, Jiajun; Dong, Na; Shan, Anshan*, Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism[J]. Journal of Medicinal Chemistry, 2017, 60 (6): 2257-2270. (IF₂₀₁₆=6.259, 中科院分区₂₀₁₇二区Top)

9. 徐博成, 王家俊, 丑淑丽, 单安山*. 细菌对抗菌肽的抗性及机理[J]. 动物营养学报, 2017, 29(6): 1874-1883.

10. Chou, Shuli; Shao, Changxuan; Wang, Jiajun; Shan, Anshan*; Xu, Lin; Dong Na; Li Zhongyu, Short, Multiple-Stranded Beta-Hairpin Peptides Have Antimicrobial Potency with High Selectivity and Salt Resistance[J]. Acta Biomaterialia, 2016, 30: 78-93. (IF₂₀₁₅=6.008, 中科院分区₂₀₁₆一区Top)

11. Zhu, Xin; Shan, Anshan*; Ma, Zhi; Xu, Wei; Wang, Jiajun; Chou, Shuli; Cheng, Baojing, Bactericidal Efficiency and Modes of Action of the Novel Antimicrobial Peptide T9W against Pseudomonas Aeruginosa[J]. Antimicrobial Agents & Chemotherapy, 2015, 59 (6): 3008-3017. (IF₂₀₁₄=4.476, 中科院分区₂₀₁₅二区Top)

12. Xu, Lin; Chou, Shuli; Wang, Jiajun; Shao, Changxuan; Li, Weizhong; Zhu, Xin; Shan, Anshan*, Antimicrobial Activity and Membrane-Active Mechanism of Tryptophan Zipper-Like Beta-Hairpin Antimicrobial Peptides[J]. Amino Acids, 2015, 47 (11): 2385-2397. (IF₂₀₁₅=3.293, 中科院分区2015三区)

13. Lv, Yinfeng; Wang, Jiajun; Gao, He; Wang, Zeyun; Dong, Na; Ma, Qingquan; Shan, Anshan*, Antimicrobial Properties and Membrane-Active Mechanism of A Potential Alpha-Helical Antimicrobial Derived from Cathelicidin PMAP-36[J]. Plos One, 2014, 9 (1): e86364. (IF₂₀₁₄=3.534, 中科院分区₂₀₁₄三区)

14. Zhu, Xin; Ma, Zhi; Wang, Jiajun; Chou, Shuli; Shan, Anshan*, Importance of Tryptophan in Transforming An Amphipathic Peptide into A Pseudomonas Aeruginosa-Targeted Antimicrobial Peptide[J]. Plos One, 2013, 9 (12): e114605. (IF₂₀₁₂=3.730, 中科院分区₂₀₁₃二区Top)

近五年授权的专利等情况

1. 兼具细菌捕获与抑菌功能的纳米抗菌肽及制备方法和应用，王家俊；高楠；房春洋；白鹏飞，ZL2023106731974，申请时间：2023.6.8，授权日2024.02.06

2. 一种HD6仿生纳米捕获肽及其制备方法和应用，王家俊；高楠；王宇靖；宋静；吕晶；单安山，CN2023104945199，申请时间：2023.05.05

3. 一种靶向真菌的抗菌肽及制备方法和应用，王家俊; 李灵雪; 孙涛涛; 单安山; 于伟康，申请日2021.11.04，授权日2023.03.07, ZL202111298404X

4. 一种广谱抗菌的α螺旋肽及其制备方法和应用，王家俊; 李文宇; 宋静; 单安山，申请日2021.10.13，授权日2023.03.31，ZL202111191231.1

5. 一种脯氨酸保护型抗酶解抗菌肽及其制备方法和应用, 王家俊; 徐浩然; 吴万鹏; 单安山, ZL202210818325.5，授权时间：2023.09.07

6. 一种高蛋白酶稳定性色氨酸富集抗菌肽的制备方法和应用, 王家俊; 李文宇; 孙佳琦; 单安山, 申请日2022.7.12，授权日2023.10.13，ZL202210817693.8

7. 一种月桂酸修饰抗酶解肽及其制备方法和应用, 王家俊; 孙宇; 于宛琪; 刘学生; 单安山, 申请日2022.7.25，授权日2023.10.17，ZL202210877482.3

8. 一种尾端锚定的α-螺旋抗菌肽GW4A及制备方法和应用，单安山; 王家俊; 宋静; 展娜; 于伟康，申请日2019.7.22，授权日2021.03.16，ZL201910659907.1

9. 基于两栖类蛙源抗菌肽的衍生肽W8及其制备方法和应用，单安山; 杨占一; 何诗琪; 王家俊, 申请日2018.11.30，授权日2021.12.14，ZL201811452513.0

10. 一种靶向抗菌肽及其制备方法和应用，单安山; 徐林; 丑淑丽; 王家俊, 申请日2016.11.25，授权日2018.08.28，ZL201611052825.3

11. 一种非完美两亲性肽W4及其制备方法和应用，单安山; 何诗琪; 杨占一; 王家俊，申请日2018.11.30，授权日2021.10.19，ZL201811452528.7

12. 一种抗菌肽VCK-17及其联合香茅醛做为抗菌药物的应用, 单安山; 杨占一; 何诗琪; 王家俊，申请日2022.09.07，授权日2023.11.24，ZL202211087472.6

13. 一种抗酶解抗菌肽N1及其制备方法和应用, 单安山; 何诗琪; 杨占一; 王家俊；申请日2022.3.16，授权日2023.07.07，ZL202210259454.5