姓名:路义鑫
性别:男
出生年月:1967-08-24
职称:教授
办公电话:18846797068
工作单位:东北农业大学
E-mail:luyixin@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
106221 分子寄生虫学 博士研究生 48
406210 兽医体系与管理 博士研究生 32
206222 兽医寄生虫病学 硕士研究生 48
306215 兽医法律法规 硕士研究生 32
206322 蜘蛛昆虫学实验技术 硕士研究生 64
106129-01 预防兽医学科前沿专题讲座 博士研究生 16
近五年主持科研项目概况

严重危害畜禽生产寄生虫病的诊断、检测与防控新技术研究----反刍动物肝片吸虫病早期诊断与控制技术研究,2017YFD0501202-2,国家重点研发计划子课题,2017-07— 2020-12

旋毛虫丝氨酸蛋白酶抑制剂在抑制宿主免疫反应中的作用机制研究,C2016030,黑龙江省基金面上项目,2016-07— 2019-07

旋毛虫丝氨酸蛋白酶抑制剂在虫体入侵宿主过程中对肠道炎症反应的调控机制研究,SKLVEB2019KFKT011,家畜疫病病原生物学国家重点实验室开放基金课题,2019-12---2021-11

近五年项目获奖概况

东北农业大学第三届校级高校教师教学创新大赛暨第三届黑龙江省高校教师教学创新大赛二等奖,2023年

近五年代表性著作、论文

1. Jing-Bo Zhen; Rui-Biao Wang; Yu-Heng Zhang; Feng Sun; Li-Hao Lin; Zhi-Xin Li; Yang Han; Yi-Xin Lu.Effects of Trichinella spiralis and its serine protease inhibitors on autophagy of host small intestinal cells.Infection and Immunity,24 October 2023 Vol. 91, No. 11

2. Ruibiao Wang; Lihao Lin; Yang Han; Zhixin Li; Jingbo Zhen; Yuheng Zhang; Feng Sun; Yixin Lu.Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2 Veterinary Research,54, 52 (2023).

3. JingBo Zhen, JinPeng Zhang, Feng Sun, LiHao Lin, YuHeng Zhang, RuiBiao Wang,Yang Han, ZhiXin Li, YiXin Lu.Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice.International Immunopharmacology,Volume119,June2023,pp.110101 

4. Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin,Feng Sun and Yixin Lu*.Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function.Veterinary Research, (2022) 53:87.https://doi.org/10.1186/s13567-022-01108-y. TOP期刊

5. Jingyun Xu, Zixuan Pang, Jinpeng Zhang, Shuang Xia, Ruibiao Wang, Yuheng Zhang, Jingbo Zhen,Xuewei Song, Lihao Lin, Feng Sun, Xinxin Xuan and Yixin Lu1*.Regulatory effects of Trichinella spiralis and a serine protease inhibitor on the endoplasmic reticulum stress response of intestinal epithelial cells.Veterinary Research, (2022) 53:18. https://doi.org/10.1186/s13567-022-01036-x. TOP期刊

6. Nana YiPengcheng YuLijia WuZhaokun LiuJingzhe GuanChang LiuMingxu LiuYixin Lu*.RNAimediated silencing of Trichinella spiralis serpintype serine protease inhibitors results in a reduction in larval infectivity. Veterinary Research,(2020) 51:139. TOP期刊

7. Yang Zou, Wen-Bin Zheng, Jun-Jun He, Hany M. Elsheikha, Xing-Quan Zhu* and Yi-Xin Lu*.Toxocara canis Differentially Affects Hepatic MicroRNA Expression in Beagle Dogs at Different Stages of Infection. Frontiers in Veterinary Science,November 2020 | Volume 7 | Article 587273

8. Jingyun Xu , Lijia Wu , Yichun Sun, Yating Wei, Lushan Zheng, Jinpeng Zhang, Zixuan Pang, Ying Yang,Yixin Lu(*),Proteomics and bioinformatics analysis of Fasciola hepatica somatic proteome in different growth phases. Parasitology Research, (2020) 119:2837—2850  https://doi.org/10.1007/s00436-020-06833-x.

9. Jingyun XuLijia WuPengcheng YuYichun Sun & Yixin Lu*.Effect of T. spiralis Serine protease inhibitors on TNBS-induced experimental colitis mediated by Macrophages. Scientific Reports,(2020) 10:3147.

10. Li Li, Zhe Hu, Jinhui Sun, Kui Guo, Xiaoyu Chu, Xiaojun Wang, Yixin Lu*.Development of an EvaGreen-based real-time PCR assay for detection of Aleutian mink disease virus. Journal of Virological Methods, 275 (2020) 113751 

11. Jingyun Xu, Pengcheng Yu, Lijia Wu, Mingxu Liu & Yixin Lu*. Regulatory effect of two Trichinella spiralis serine protease inhibitors on the host’s immune system. scientific reports,(2019) 9:17045 | https://doi.org/10.1038/s41598-019-52624-5

12. Jingyun Xu, Mingxu Liu, Pengcheng Yu, Lijia Wu, Yixin Lu*. Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-inducedexperimental inflammatory bowel disease in mice. International Immunopharmacology. 66201928-40.

13. Jingyun Xu, Pengcheng Yu, Lijia Wu, Mingxu Liu, Yixin Lu*.Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice.Immunobiology,2242019147-153

近五年授权的专利等情况
其他获奖及荣誉称号
黑龙江省高层次人才