课程编号 | 课程名称 | 课程级别 | 学时 |
(1) 国家自然科学基金委员会,
青年科学基金项目,
32002215, 高稳定脂酰肽的分子设计、纳米组装体构建及猪肠道内抗菌效力研究, 2021-01-01 至 2023-12-31,24万元,结题,主持
(2) 黑龙江省人社厅, 黑龙江省博士后面上项目,
LBH-Z21003, 脂酰化富脯氨酸肽分子的全新设计、纳米组装体构建及其体内应用效果研究, 2021-12 至 2024-12, 10万元, 在研, 主持
(3) 东北农业大学, “东农学者”学术骨干项目(人才引进),
19YJXG05, 疏水性氨基酸尾端锚定结构对抗菌肽生物学活性的影响, 2019-09 至 2024-09, 30万元, 在研,主持
(4) 中国博士后基金委, 中国博士后面上项目, 2021M690576, 抗酶解型Trp富集肽的分子设计、构效关系及抗菌机制研究,
2021-06 至 2024-06, 8万元, 在研,主持
(5) 黑龙江省科技厅, 黑龙江省自然科学基金优秀青年项目,
YQ2020C009, 抗酶解β-折叠肽的全新设计及其对腹泻断奶仔猪肠道健康的影响, 2020-07 至 2023-07, 10万元, 结题,主持
(6) 黑龙江省人社厅, 黑龙江省博士后特别资助项目,LBH-TZ2305,纳米靶向捕获肽分子骨架设计及其对腹泻仔猪肠屏障功能影响的研究,2023年12至今,30万元,在研,主持
(1)
2020年度帝斯曼缤纷科技奖——动物营养科学青年学者奖-优胜奖
(2) 2020年度黑龙江省优青
(3)
2021年度黑龙江省研究生导学思政团队(导师)——非粮型饲料资源研发研究生导学思政团队
(4) 2022年度颐和青年奖——新锐奖
(5)
2023年中国畜牧兽医学会动物营养学分会第六届青年学者讲坛——优秀报告
(6)
2023年饲料创新研究生论坛—优胜奖(指导教师)
1. 第一作者或通讯作者
1.
Gao, Nan; Wang, Jiajun*; Fang, Chunyang; Bai,
Pengfei; Sun, Yu; Wu, Wanpeng; Shan, Anshan*. Combating bacterial infections with host
defense peptides: Shifting focus from bacteria to host immunity. DRUG
RESISTANCE UPDATES, 2023, 72: 10103 (IF2022=24.3, 中科院分区2023一区Top)
2.
Su, Yunzhe; Sun, Taotao; Gao, Junhan; Zhang,
Chenxu; Liu, Xuesheng; Bi, Chongpeng; Wang, Jiajun*; Shan, Anshan*. Anti-Proteolytic
Peptide R7I Protects the Intestinal Barrier and Alleviates Fatty Acid
Malabsorption in Salmonella Typhimurium-Infected Mice. INTERNATIONAL JOURNAL OF
MOLECULAR SCIENCES, 2023, 24:22 (IF2022=5.6, 中科院分区2023二区)
3.
Yang, Zhanyi; He, Shiqi; Wei, Yingxin; Li, Xuefeng;
Shan, Anshan*; Wang, Jiajun*, Antimicrobial peptides in combination with citronellal efficiently
kills multidrug resistance bacteria. PHYTOMEDICINE, 2023,
120: 155070 (IF2022=7.9, 中科院分区2023一区Top)
4.
He, Shiqi; Yang, Zhanyi; Li, Xuefeng; Wu, Hua;
Zhang, Licong; Shan, Anahsn*; Wang, Jiajun*, Boosting Stability and Therapeutic
Potential of Proteolysis-Resistant Antimicrobial Peptides by End-Tagging
β-Naphthylalanine. Acta Biomaterialia, 2023, 164:175-194. (IF2022=9.7, 中科院分区2023一区Top)
5.
Yu, Weikang; Sun, Yu; Li, Wenyu; Guo, Xu.; Liu,
Xuesheng; Wu, Wanpeng; Yu, Wanqi; Wang, Jiajun*; Shan, Anshan*, Self-Assembly
of Antimicrobial Peptide-Based Micelles Breaks the Limitation of Trypsin. ACS
Applied Materials & Interfaces, 2022,15(1):494-510 ( IF2021=10.383,
中科院分区2022二区Top)
6.
Sun, Taotao; Liu, Xuesheng; Su, Yunzhe; Wang,
Zihang; Cheng, Baojing; Dong, Na; Wang, Jiajun*;
Shan, Anshan*. The Efficacy of Anti-Proteolytic Peptide R7I in Intestinal
Inflammation, Function, Microbiota, and Metabolites by Multi-Omics Analysis in
Murine Bacterial Enteritis. Bioengineering & Translational Medicine. 2023,
8 (2). (IF2021=10.684, 中科院分区2022二区)
7.
He, Shiqi; Yang, Zhanyi; Li, Xuefeng; Wu, Hua;
Zhang, Licong; Wang, Jiajun*; Shan, Anshan*, Optimized Proteolytic Resistance
Motif (DabW)-Based U1-2WD: A Membrane-Induced Self-Aggregating Peptide to
Trigger Bacterial Agglutination and Death. Acta Biomaterialia, 2022, 153,
540-556. (IF2021=10.633, 中科院分区2022一区Top)
8.
Wang, Jiajun*; Li, Wenyu; KHosravi-Darani,
Kianoush; Kim, In Ho, Editorial: The Development and Utilization of Novel
Antibiotic Alternatives. Frontiers in Microbiology, 2022, 13:1008850. (IF2021=6.064,
中科院分区2022二区Top)
10.
Yu, Weikang#; Wang, Jiajun#;
Wang, Zihang; Li, Lingxue; Li, Wenyu; Song, Jing; Zhang, Shanshan; Shan,
Anshan*, PEGylation of the Antimicrobial Peptide PG-1: A Link between
Propensity for Nanostructuring and Capacity of the Antitrypsin Hydrolytic
Ability[J]. Journal of Medicinal Chemistry, 2021, 64 (14): 10469-10481. (IF2020=7.446,
中科院分区(升级)2021一区Top)
11. 于伟康,张珊珊,杨占一,王家俊*,单安山*.超分子多肽自组装在生物医学中的应用[J].生物工程学报, 2021, 37
(07):2240-2255.
12.
Yang, Yang; Wang, Chenxi; Gao, Nan; Lyu, Yinfeng;
Zhang, Licong; Zhang, Sujiang; Wang, Jiajun*; Shan, Anshan*, A Novel
Dual-Targeted α-Helical Peptide with Potent Antifungal Activity against
Fluconazole-Resistant Candida Albicans Clinical Isolates[J]. Frontiers in
Microbiology, 2020, 11 (548620). (IF2019=4.236,中科院分区(升级)2020二区Top)
13. He, Shiqi;
Yang, Zhanyi; Yu, Weikang; Li, Jiawei; Li, Zhongyu; Wang, Jiajun*; Shan,
Anshan*, Systematically Studying the Optimal Amino Acid Distribution Patterns
of the Amphiphilic Structure by Using the Ultrashort Amphiphiles[J]. Frontiers
in Microbiology, 2020, 11:569118. (IF2019=4.236,中科院分区(升级)2020二区Top)
14. Wang, Jiajun;
Dou, Xiujing; Song, Jing; Lyu, Yinfeng; Zhu, Xin; Xu, Lin; Li, Weizhong; Shan,
Anshan*, Antimicrobial Peptides: Promising Alternatives in the Post Feeding
Antibiotic era[J], Medicinal Research Reviews, 2019, 39 (3): 831-859. (IF2018=9.791,
中科院分区(升级)2019一区Top, 热点文章)
15. Song, Jing#;
Wang, Jiajun#; Zhan, Na; Sun, Taotao; Yu, Weikang; Zhang, Licong;
Shan, Anshan*; Zhang, Aizhong, Therapeutic Potential of Trp-Rich Engineered
Amphiphiles by Single Hydrophobic Amino Acid End-Tagging, ACS Applied Materials
& Interfaces, 2019, 11 (47): 43820-43834. (IF2018=8.456, 中科院分区(升级)2019一区Top)
16. Wang, Jiajun#;
Song, Jing#; Yang, Zhanyi; He, Shiqi; Yang, Yi; Feng, Xingjun; Dou, Xiujing;
Shan, Anshan*, Antimicrobial Peptides with High Proteolytic Resistance for
Combating Gram-Negative Bacteria[J], Journal of Medicinal Chemistry, 2019, 62
(5): 2286-2304. (IF2018=6.054, 中科院分区(升级)2019一区Top)
17. Chou, Shuli#;
Wang, Jiajun#; Shang, Lu; Akhtar Muhammad Usman; Wang, Zhihua; Shi,
Baoming; Feng, Xingjun; Shan, Anshan*, Short, Symmetric-Helical Peptides Have
Narrow-Spectrum Activity with Low Resistance Potential and High Selectivity[J].
Biomaterials Science, 2019, 7 (6): 2394-2409.(IF2018=5.251, 中科院分区(升级)2019二区)
18. Wang, Jiajun#;
Chou, Shuli#; Yang, Zhanyi; Yang, Yang; Wang, Zhihua; Song, Jing;
Dou, Xiujing; Shan, Anshan*, Combating Drug-Resistant Fungi with Novel
Imperfectly Amphipathic Palindromic Peptides[J]. Journal of Medicinal
Chemistry, 2018, 61 (9): 3889-3907. (IF2017=6.253, 中科院分区(升级)2018一区)
19. Wang, Jiajun;
Chou, Shuli; Xu, Lin; Zhu, Xin; Dong, Na; Shan, Anshan*; Chen Zhihui, High
Specific Selectivity and Membrane-Active Mechanism of the Synthetic
Centrosymmetric Alpha-Helical Peptides with Gly-Gly Pairs[J]. Scientific
Reports, 2015, 5: 15963. (IF2014=5.578, 中科院分区2015二区)
2. 非第一作者或通讯作者
1.
Yang, Zhanyi; Wei, Yingxin; Wu, Wanpeng; Zhang,
Licong; Wang, Jiajun; Shan, Anshan*, Characterization of Simplified
Nonapeptides with Broad-Spectrum Antimicrobial Activities as Potential Food
Preservatives, and Their Antibacterial Mechanism. Food & Function, 2023, 14
(7), 3139-3154. (IF2021=6.317, 中科院分区2022一区Top)
2.
Zhan, Na; Zhang, Licong; Yang, Hong; Zheng, Yanlan;
Wei, Xinke; Wang, Jiajun; Shan, Anshan*, Design and Heterologous Expression of
A Novel Dimeric LL37 Variant in Pichia Pastoris[J]. Microbial Cell Factories,
2021, 20 (1): 13. (IF2020=5.328,中科院分区2021二区)
3. 张珊珊,宋静,王家俊,单安山*.细菌生物膜的形成及抗菌肽抗生物膜活性的研究进展.动物营养学报, 2021
4. Wang, Chensi;
Shao, Changxuan; Fang, Yuxin; Wang, Jiajun; Dong, Na; Shan, Anshan*, Binding
Loop of Sunflower Trypsin Inhibitor 1 Serves as A Design Motif for
Proteolysis-Resistant Antimicrobial Peptides. Acta Biomaterialia.2021. 124:
254-269. (IF2020=8.947,中科院分区2021一区Top)
5. Li, Jiawei;
Shang, Lu; Lan, Jing; Chou, Shuli; Feng, Xingjun; Shi, Baoming; Wang, Jiajun;
Lyu, Yinfeng; Shan, Anshan*, Targeted and Intracellular Antibacterial Activity
against S. galactiae of the Chimeric Peptides Based on Pheromone and
Cell-Penetrating Peptides[J]. ACS Applied Materials & Interfaces, 2020, 12
(40): 44459-44474. (IF2019=8.758,中科院分区2020一区Top)
6. Xu, Lin; Shao,
Changxuan; Li, Guoyu; Shan, Anshan; Chou, Shuli; Wang, Jiajun; Ma, Qingquan;
Dong, Na, Conversion of Broad-Spectrum Antimicrobial Peptides into
Species-Specific Antimicrobials Capable of Precisely Targeting Pathogenic
Bacteria[J]. Scientific Reports, 2020, 10 (1): 944. (IF2019=3.998,中科院分区2020三区)
7. Yang, Zhanyi;
He, Shiqi; Wang, Jiajun; Yang, Yi; Zhang, Licong; Li, Yanbing; Shan, Anshan*,
Rational Design of Short Peptide Variants by Using Kunitzin-RE, An
Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum
Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of
Pathogens[J]. Journal of Medicinal Chemistry, 2019, 62 (9): 4586-4605. (IF2018=6.054,
中科院分区(升级)2019一区Top)
8. Dou, Xiujing;
Zhu, Xin; Wang, Jiajun; Dong, Na; Shan, Anshan*, Novel Design of Heptad
Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm
Properties and Their Membrane-Disruptive Mechanism[J]. Journal of Medicinal
Chemistry, 2017, 60 (6): 2257-2270. (IF2016=6.259, 中科院分区2017二区Top)
9. 徐博成, 王家俊, 丑淑丽, 单安山*. 细菌对抗菌肽的抗性及机理[J].
动物营养学报,
2017, 29(6): 1874-1883.
10. Chou, Shuli;
Shao, Changxuan; Wang, Jiajun; Shan, Anshan*; Xu, Lin; Dong Na; Li Zhongyu,
Short, Multiple-Stranded Beta-Hairpin Peptides Have Antimicrobial Potency with
High Selectivity and Salt Resistance[J]. Acta Biomaterialia, 2016, 30: 78-93.
(IF2015=6.008, 中科院分区2016一区Top)
11. Zhu, Xin; Shan,
Anshan*; Ma, Zhi; Xu, Wei; Wang, Jiajun; Chou, Shuli; Cheng, Baojing,
Bactericidal Efficiency and Modes of Action of the Novel Antimicrobial Peptide
T9W against Pseudomonas Aeruginosa[J]. Antimicrobial Agents & Chemotherapy,
2015, 59 (6): 3008-3017. (IF2014=4.476, 中科院分区2015二区Top)
12. Xu, Lin; Chou,
Shuli; Wang, Jiajun; Shao, Changxuan; Li, Weizhong; Zhu, Xin; Shan, Anshan*,
Antimicrobial Activity and Membrane-Active Mechanism of Tryptophan Zipper-Like
Beta-Hairpin Antimicrobial Peptides[J]. Amino Acids, 2015, 47 (11): 2385-2397.
(IF2015=3.293, 中科院分区2015三区)
13. Lv, Yinfeng;
Wang, Jiajun; Gao, He; Wang, Zeyun; Dong, Na; Ma, Qingquan; Shan, Anshan*,
Antimicrobial Properties and Membrane-Active Mechanism of A Potential
Alpha-Helical Antimicrobial Derived from Cathelicidin PMAP-36[J]. Plos One,
2014, 9 (1): e86364. (IF2014=3.534, 中科院分区2014三区)
14. Zhu, Xin; Ma,
Zhi; Wang, Jiajun; Chou, Shuli; Shan, Anshan*, Importance of Tryptophan in
Transforming An Amphipathic Peptide into A Pseudomonas Aeruginosa-Targeted
Antimicrobial Peptide[J]. Plos One, 2013, 9 (12): e114605. (IF2012=3.730,
中科院分区2013二区Top)
1.
兼具细菌捕获与抑菌功能的纳米抗菌肽及制备方法和应用, 王家俊;高楠;房春洋;白鹏飞,ZL2023106731974,申请时间:2023.6.8,授权日2024.02.06
2.
一种HD6仿生纳米捕获肽及其制备方法和应用,王家俊;高楠;王宇靖;宋静;吕晶;单安山,CN2023104945199,申请时间:2023.05.05
3.
一种靶向真菌的抗菌肽及制备方法和应用,王家俊; 李灵雪; 孙涛涛; 单安山; 于伟康,申请日2021.11.04,授权日2023.03.07,
ZL202111298404X
4.
一种广谱抗菌的α螺旋肽及其制备方法和应用,王家俊; 李文宇; 宋静; 单安山, 申请日2021.10.13,授权日2023.03.31,ZL202111191231.1
5.
一种脯氨酸保护型抗酶解抗菌肽及其制备方法和应用, 王家俊; 徐浩然; 吴万鹏; 单安山, ZL202210818325.5, 授权时间:2023.09.07
6.
一种高蛋白酶稳定性色氨酸富集抗菌肽的制备方法和应用, 王家俊; 李文宇; 孙佳琦; 单安山, 申请日2022.7.12,授权日2023.10.13,ZL202210817693.8
7.
一种月桂酸修饰抗酶解肽及其制备方法和应用, 王家俊; 孙宇; 于宛琪; 刘学生; 单安山, 申请日2022.7.25,授权日2023.10.17,ZL202210877482.3
8.
一种尾端锚定的α-螺旋抗菌肽GW4A及制备方法和应用,单安山; 王家俊; 宋静; 展娜; 于伟康,申请日2019.7.22,授权日2021.03.16,ZL201910659907.1
9.
基于两栖类蛙源抗菌肽的衍生肽W8及其制备方法和应用,单安山; 杨占一; 何诗琪; 王家俊, 申请日2018.11.30, 授权日2021.12.14,ZL201811452513.0
10.
一种靶向抗菌肽及其制备方法和应用,单安山; 徐林; 丑淑丽; 王家俊, 申请日2016.11.25,授权日2018.08.28,ZL201611052825.3
11.
一种非完美两亲性肽W4及其制备方法和应用,单安山; 何诗琪; 杨占一; 王家俊,申请日2018.11.30,授权日2021.10.19,ZL201811452528.7
12.
一种抗菌肽VCK-17及其联合香茅醛做为抗菌药物的应用, 单安山; 杨占一; 何诗琪; 王家俊, 申请日2022.09.07,授权日2023.11.24,ZL202211087472.6
13.
一种抗酶解抗菌肽N1及其制备方法和应用, 单安山; 何诗琪; 杨占一; 王家俊
;申请日2022.3.16,授权日2023.07.07,ZL202210259454.5
14. 一种抗酶解抗菌肽U1-2WD及其制备方法和应用, 单安山; 何诗琪; 杨占一; 王家俊, 申请日2022.03.16, 授权日2023.06.30,ZL202210258550.8
(1)
2020年度帝斯曼缤纷科技奖——动物营养科学青年学者奖-优胜奖
(2) 2020年度黑龙江省优青
(3)
2021年度黑龙江省研究生导学思政团队(导师)——非粮型饲料资源研发研究生导学思政团队
(4) 2022年度颐和青年奖——新锐奖
(5)
2023年中国畜牧兽医学会动物营养学分会第六届青年学者讲坛——优秀报告
(6)
2023年饲料创新研究生论坛—优胜奖(指导教师)