姓名:白靖文
性别:男
出生年月:1978-01-01
职称:教授
办公电话:045155190417
工作单位:东北农业大学
E-mail:baijingwen@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
211228 学术论文写作与学术规范 博士课 16
311204 高等药物化学 硕士课 32
近五年主持科研项目概况

[1] 大黄素通过CcpA靶标抑制猪链球菌葡萄糖代谢的分子机制,国家自然基金(面上项目),58万,主持人,2022.01-2026.12.

[2] 基于D-葡萄糖能量代谢途径探究大黄酚对猪链球菌抑菌机制,黑龙江省自然科学基金, 10万元,主持人,2021.07-2024.06.

[3] 基于PTS转运通路研究大黄酚干预猪链球菌生物被膜形成作用机制,黑龙江省博士后基金,10万元,主持人,2020.1-2022.12.

[4] 基于LuxS靶标药效团模型筛选干预木葡菌生物被膜先导药物及作用机制,黑龙江省自然科学基金,6万元,主持人,2018.7-2020.6.

[5] 治疗猪细菌性呼吸道疾病中兽药活性先导化合物HTD筛选及作用机制研究( CARS-35-007),国家生猪产业技术体系子课题,16万,主持人, 2017.1-2020.12.

[6] 致奶牛乳房炎细菌生物被膜抑制剂研究,哈尔滨市基金,10万元,主持人,2017.1-2019.12.

近五年项目获奖概况

[1] 民猪优异种质特性遗传机制、新品种培育及产业化,国家科学技术进步奖,二等奖,参加,中华人民共和国国务院,2017.12.6.

[2] 指导研究生唐阳、崔文强获奖, 干预猪链球菌生物被膜形成中兽药大黄药效物质分离纯化, 黑龙江省第五届知识产权杯高校创新发明竞赛二等奖, 黑龙江省知识产权局, 2019,11.

[3] 指导研究生白雪冬,杨镇远,李健强,一种饲料添加剂—丁香油纳米制剂的制备,第六届黑龙江省“GAM”杯创新创业大赛一等奖,中国林学会木材科学分会,2021.07.

[4] 指导研究生白雪冬,杨镇远,李健强,一种饲料添加剂—丁香油纳米制剂的制备,第六届黑龙江省“GAM”杯创新创业大赛雏鹰奖,中国林学会木材科学分会,2021.07.

近五年代表性著作、论文

共发表中英文论文50余篇,其中,第一(通讯)作者发表中科院大类一区代表性论文如下: 

[1] Ultrasound-assisted extraction of emodin from Rheum officinale Baill and its antibacterial mechanism against Streptococcus suis based on CcpA. Ultrasonics Sonochemistry, 2024,102:106733. (中科院大类一区, IF= 8.4). 

[2] Discovery of natural agents against Staphylococcus aureus based on EIIC by protein modeling, virtual screening and molecular dynamics, LWT - Food Science and Technology, 2024, 198: No. 115914.(中科院大类一区, IF= 6.0)

[3] Extraction and characterization of polysaccharides from blackcurrant fruits and its inhibitory effects on acetylcholinesterase. International Journal of Biological Macromolecules, 2024, 262: 130047. (中科院大类一区, IF= 8.2).

[4] Microwave-assisted aqueous two-phase extraction of polysaccharides from Hippophae rhamnoide L.: Modeling, characterization and hypoglycemic activity. International Journal of Biological Macromolecules, 2024, 254: 127626. (中科院大类一区, IF= 8.2).

[5] Antimicrobial activity and mechanism of Magnolia officinalis root extract against methicillin-resistant Staphylococcus aureus based on mannose transporter. Industrial Crops and Products, 2023, 201: 116953. (中科院大类一区, IF= 6.5). 

[6] The activity and mechanism of vidofludimus as a potent enzyme inhibitor against NDM-1-positive E. coli. European Journal of Medicinal Chemistry, 2023, 2: No. 115225. (中科院大类一区, IF= 7.1). 

[7] A novel procedure for simultaneous extraction of polysaccharides and polyphenols from Schisandra Chinensis: Modeling, characterization and biological properties. Industrial Crops and Products, 2023,193: No. 116208. (中科院大类一区, IF= 6.5). 

[8] Preparation of Ribes nigrum L. polysaccharides-stabilized selenium nanoparticles for enhancement of the anti-glycation and α-glucosidase inhibitory activities. International Journal of Biological Macromolecules, 2023, 253: 127122. (中科院大类一区, IF= 8.2). 

[9] Antibacterial activity and mechanism of clove essential oil against foodborne pathogens. LWT - Food Science and Technology, 2023,173: No. 114249. (中科院大类一区, IF= 6.0). 

[10] Degradation of blue honeysuckle polysaccharides, structural characteristics and antiglycation and hypoglycemic activities of degraded products. Food Research International, 2021, No.110281. (中科院大类一区,IF= 7.4). 

[11] Simultaneous extraction of polysaccharides and polyphenols from blackcurrant fruits: Comparison between response surface methodology and artificial neural networks. Industrial Crops and Products,2021,170:No.113682. (中科院大类一区,IF=6.5). 

[12] Characterization of selenized polysaccharides from Ribes nigrum L. and its inhibitory effects on α-amylase and α-glucosidase. Carbohydrate Polymers , 2021, 259:NO.117729. (中科院大类一区,IF= 11.2). 

[13] Degradation models, structure, rheological properties and protective effects on erythrocyte hemolysis of the polysaccharides from Ribes nigrum L.. International Journal of Biological Macromolecules, 2020, 165: 738-746.(中科院大类一区, IF= 8.2). 

[14] Microwave-assisted aqueous two-phase extraction of phenolic compounds from Ribes nigrum L. and its antibacterial effect on foodborne pathogens. Food Control, 2021, 119: No. 107449. (中科院大类一区,IF=6.0).

近五年授权的专利等情况

[1] 和厚朴酚在抑制猪链球菌或其生物被膜中的用途, 授权号:ZL202010137016.2, 授权公告日:2023年08月18日,申请日:2020-03-02.

[2] 一种同时制备黑穗醋栗多酚及多糖的方法, 授权专利号:ZL202010231659.3, 授权公告日:2022.01.18,申请日:2020-03-27.

[3] 一种北五味子果实中活性成分集成提取的方法,授权专利号:ZL202111180006.82022.12.23授权,申请日:2021-10-11.

[4] 一种大豆分离蛋白水解物-五味子多糖运载槲皮素的抗菌乳液制备方法,申请号:CN202311286162.1,申请日:2023108.

[5] 一种集成共提平贝生物碱及多糖的方法,申请号:CN202311206472.8,申请日:20230918.

[6] 一种温度响应型深共晶双水相体系同时提取北五味子多糖和多酚的方法,申请号:CN202311094637.7,申请日:20230829.

[7] 一种固定化酶联合高压提取刺五加苷B的方法,CN202211348217.2,申请日:20221213.

[8] 一种静态高压联合果胶酶降解黑穗醋栗多糖的方法,CN202211601202.2,申请日:20221031.

[9] 一种北五味子果实中多糖的提取方法,CN202310705026.5,申请日:20230614.

[10] 一种共载巴西苏木素和链霉素协同抗菌脂质体的制备方法及应用,CN202311134797.X, 申请日:20230904日.

其他获奖及荣誉称号

[1] 国家动物健康与食品安全创新联盟理事;

[2] 中国畜牧兽医学会药理毒理学分会理事;

[3] 黑龙江省畜牧兽医学会理事;

[4] 黑龙江省师德先进个人; 

[5] 东北农业大学教学能手;

[6] 东北农业大学优秀共产党员;

[7] 东北农业大学教书育人先进个人.