姓名:杨昱
性别:女
出生年月:1977-12-01
职称:教授
办公电话:045155190930
工作单位:东北农业大学
E-mail:yangyu@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
111305 天然药物专题 博士课 32
109333 代谢调控与产物化学(双语) 博士课 32
311201 糖化学基础 硕士课 32
211312 生物无机化学 硕士课 32
近五年主持科研项目概况

[1] 国家自然科学基金青年项目,超声波降解改善黑穗醋栗果实多糖降血糖活性作用机制及构效关系研究,31600276,国家自然科学基金委员会,A类科研项目,2017.01-2019.12,20万,结题,主持人。

[2] 国家生猪产业技术体系子课题,中兽药质量标准的确定,CARS-35-001,国家生猪产业技术体系,B类科研项目,2022.07-2025.07,10万,在研,主持人。

[3] 黑龙江省博士后落地启动基金项目,黑穗醋栗多糖化学修饰及抗2型糖尿病作用机制研究,LBH-Q17030,黑龙江省博士后管理办公室,C类科研项目,2018.01-2019.12,6万,结题,主持人。

[4] 国家自然科学基金面上项目,大黄素通过CcpA靶标抑制猪链球菌葡萄糖代谢的分子机制,32172916,国家自然科学基金委员会,A类科研项目,2022.01-2025.12,58万,在研,第二参加人。

[5] 黑龙江省自然科学基金面上项目,基于D-葡萄糖能量代谢途径探究大黄酚对猪链球菌抑菌机制,LH2021C044,黑龙江省科学技术厅,B类科研项目,2021.07-2024.07,10万,在研,第二参加人。

[6] 黑龙江省自然科学基金面上项目,基于LuxS靶标药效团模型筛选干预木葡菌生物被膜先导药物及作用机制,C2018013,黑龙江省自然科学基金委员会,B类科研项目,2018.07-2021.07,6万,结题,第二参加人。

近五年项目获奖概况

[1] 指导研究生唐阳、崔文强获奖, 干预猪链球菌生物被膜形成中兽药大黄药效物质分离纯化, 黑龙江省第五届知识产权杯高校创新发明竞赛二等奖, 黑龙江省知识产权局, 2019,11.

[2] 指导研究生白雪冬,杨镇远,李健强,一种饲料添加剂—丁香油纳米制剂的制备,第六届黑龙江省“GAM”杯创新创业大赛一等奖,中国林学会木材科学分会,2021.07.

近五年代表性著作、论文

(1) Zhiyuan Chen, Miao Li, Yujia Guo, Jianqiang Li, Chi Wei, Jiaying Han, Chunhong Liu, Jingwen Bai*, Yu Yang*. Discovery of natural agents against Staphylococcus aureus based on EIIC by protein modeling, virtual screening and molecular dynamics, LWT - Food Science and Technology, 2024, 198: No. 115914. (SCI,中科院大类一区, IF= 6.0)

(2) Yu Yang, Jiaheng Zou, Miao Li, Yang Yun, Jianqiang Li, Jingwen Bai *. Extraction and characterization of polysaccharides from blackcurrant fruits and its inhibitory effects on acetylcholinesterase. International Journal of Biological Macromolecules, 2024, 262: 130047. (SCI,中科院大类一区, IF= 8.2).

(3) Jingwen Bai, Yu Xie, Miao Li, Xianjun Huang, Yujia Guo, Jingwen Sun, Yang Tang, Xuantong Liu, Chi Wei, Jianqiang Li, Yu Yang*.  Ultrasound-assisted extraction of emodin from Rheum officinale Baill and its antibacterial mechanism against Streptococcus suis based on CcpA. Ultrasonics Sonochemistry, 2024,102:106733. (SCI,中科院大类一区, TOP, IF= 8.4).

(4) Yu Yang, Miao Li, Jingwen Sun, Shuhui Qin, Tengteng Diao, Jingwen Bai*, Yanhua Li *. Microwave-assisted aqueous two-phase extraction of polysaccharides from Hippophae rhamnoide L.: Modeling, characterization and hypoglycemic activity. International Journal of Biological Macromolecules, 2024, 254: 127626. (SCI,中科院大类一区, TOP, IF= 8.2).

(5) Meimei Zhao, Yunzhou Wu, Fan Zhang, Sitao Zheng, Libo Wang, Jingwen Bai*, Yu Yang*. Preparation of Ribes nigrum L. polysaccharides-stabilized selenium nanoparticles for enhancement of the anti-glycation and α-glucosidase inhibitory activities. International Journal of Biological Macromolecules, 2023, 253: 127122. (SCI,中科院大类一区, TOP, IF= 8.2).

(6) Jingwen Sun, Yu Xie, Zhiyuan Chen, Yipin Fan, Yunfeng Liu, Qi Gao, Jianqiang Li, Jingwen Bai *, Yu Yang *. Antimicrobial activity and mechanism of Magnolia officinalis root extract against methicillin-resistant Staphylococcus aureus based on mannose transporter. Industrial Crops and Products, 2023, 201: 116953. (SCI,中科院大类一区, TOP, IF= 5.9).

(7) Fan Zhang, Yaqin Xu, Xueying Bu, Zitong Wang, Shilong Qi, Dalong Li, Libo Wang, Jingwen Bai*, Yu Yang*, A novel procedure for simultaneous extraction of polysaccharides and polyphenols from Schisandra Chinensis: Modeling, characterization and biological properties. Industrial Crops and Products, 2023,193: No. 116208. (SCI,中科院大类一区, TOP, IF= 6.4).

(8) Jingwen Bai, Jianqiang Li, Zhiyuan Chen, Xuedong Bai, Zhenyuan Yang, Zitong Wang, Yu Yang*. Antibacterial activity and mechanism of clove essential oil against foodborne pathogens. LWT - Food Science and Technology, 2023,173: No. 114249.  (SCI,中科院大类一区, TOP, IF= 6.0).

(9) Junwen Liu, Jingwen Bai, Chuntian Shao, Shengnan Yao, Ran Xu, Suyang Duan, Libo Wang, Yaqin Xu* and Yu Yang*. Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities. Journal of The Science of Food and Agriculture, 2023, 103(6): 3168-3183. (SCI,中科院大类二区, TOP, IF= 4.1)

(10) Zhao, Meimei, Li, Dalong, Xu, Yaqin, Bu, Xueying, Shen, Chen, Wang, Libo, Yang, Yu*, Bai, Jingwen*. Separation, kinetics of purification of syringin by macroporous resin from Syringa oblata Lindl. leaves and the evaluation of bioactivities. Pigment & Resin Technology, 2022, 51 (2) :140-148. (SCI,中科院大类四区, IF= 1.1).

(11) Xueying Bu, Yaqin Xu, Meimei Zhao, Dalong Li, Jiaheng Zou, Libo Wang, Jingwen Bai*, Yu Yang*. Simultaneous extraction of polysaccharides and polyphenols from blackcurrant fruits: Comparison between response surface methodology and artificial neural networks. Industrial Crops and Products, 2021,170:No.113682. (SCI,中科院大类一区,TOP, IF=6.4).

(12) Yu Yang, Chang, Sam K. C., Yan Zhang. Determination of protease inhibitors, glycinin, and beta-conglycinin in soybeans and their relationships. Journal of Food Science. 2022, 87(3):1082–1095. (SCI,中科院大类二区, IF= 3.9).

(13) Jingwen Bai, Xuedong Bai, Yu Yang*, Bo Tao. Extraction of allelochemicals from germinated wheat seeds and their inhibitory effects on cucumber. Agronomy Journal, 2021,06:1-12. (SCI,中科院大类三区, IF= 2.6).

(14) Meimei Zhao#, Jingwen Bai#, Xueying Bu, Yuting Yin, Libo Wang, Yu Yang*, Yaqin Xu*. Characterization of selenized polysaccharides from Ribes nigrum L. and its inhibitory effects on α-amylase and α-glucosidase. Carbohydrate Polymers , 2021, 259:NO.117729. (SCI, 中科院大类一区,TOP, IF= 11.2). 

(15) Haihong Yang, Jingwen Bai, Conglei Ma, Libo Wang, Xiaoqing Li, Yu Zhang, Yaqin Xu*, Yu Yang*. Degradation models, structure, rheological properties and protective effects on erythrocyte hemolysis of the polysaccharides from Ribes nigrum L.. International Journal of Biological Macromolecules, 2020, 165: 738-746.(SCI, 中科院大类一区, TOP, IF= 8.2).

(16) Meimei Zhao, Jingwen Bai, Xueying Bu, Yang Tang, Wenqing Han, Dalong Li, Libo Wang, Yu Yang*, Yaqin Xua**. Microwave-assisted aqueous two-phase extraction of phenolic compounds from Ribes nigrum L. and its antibacterial effect on foodborne pathogens. Food Control, 2021, 119: No. 107449. (SCI, 中科院大类一区, ESI高被引, IF=6.0).

(17) Yu Yang, Zexia Lei, Meimei Zhao, Changzong Wu, Libo Wang, Yaqin Xu*. Microwave-assisted extraction of an acidic polysaccharide from Ribes nigrum L.: Structural characteristics and biological activities. Industrial Crops & Products, 2020, 147: No.112249. (SCI, 中科院大类一区, Top, IF=5.9).

(18) Changzong Wu, Meimei Zhao, Xueying Bu, Ziya Qing, Libo Wang, Yaqin Xu, Yu Yang*, Jingwen Bai*. Preparation, characterization, antioxidant and antiglycation activities of selenized polysaccharides from blackcurrant. RSC Advances, 2020, 10(54): 32616-32627. (SCI, 中科院大类三区, IF=3.9).

(20) Jingwen Bai, Xiaoting Wang, Meiqi Hao, He Li, Guangdong Cheng, Di Liu, Yu Yang*, Yanhua Li*. Forsythiaside attenuates Escherichia coli lipopolysaccharide-induced liver acute inflammatory response in chicken, European Journal of Inflammation, 2019, 17: No. UNSP 2058739219826793, 1–7. (SCI, 中科院大类四区, IF=0.424).

(21) Yaqin Xu, Yingying Guo, Suyang Duan, Hong Wei, Yusong Liu, Libo Wang, Xin Huo, Yu Yang*. Effects of ultrasound irradiation on the characterization and bioactivities of the polysaccharide from blackcurrant fruits. Ultrasonics Sonochemistry, 2018, 49: 206–214. (SCI, 中科院大类一区, Top, IF=8.4).

(22) Yaqin Xu, Xiaojie Niu, Ningyue Liu, Yankang Gao, Libo Wang, Gang Xu, Xingguo Li, Yu Yang*. Characterization, antioxidant and hypoglycemic activities of degraded polysaccharides from blackcurrant (Ribes nigrum L.) fruits. Food Chemistry, 2018, 243: 26-35. (SCI, ESI高被引,ESI热点论文,中科院大类一区, Top, IF=8.8).

(23) Yaqin Xu, Yingying Guo, Yankang Gao, Xiaojie Niu, Libo Wang, Xingguo Li, Hongchao Chen, Zeyuan Yu, Yu Yang*. Seperation, characterization and inhibition on α-glucosidase, α-amylase and glycation of a polysaccharide from blackcurrant fruits. LWT-Food Science and Technology, 2018, 93: 16-23. (SCI, 中科院大类一区, Top, IF=6.0).

(24) Yaqin Xu, Gaijie Liu, Zeyuan Yu, Xiumei Song, Xingguo Li, Yu Yang*, Libo Wang. Purification, characterization and antiglycation activity of a novel polysaccharide from blackcurrant. Food Chemistry, 2016, 199: 694-701. (SCI, 中科院大类一区, Top, IF=8.8).

(25) Yaqin Xu, Fei Cai, Zeyuan Yu, Ling Zhang, Xingguo Li, Yu Yang*, Gaijie Liu. Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity. Food Chemistry, 2016, 194, 650-658.  ESI高被引, 中科院二区(Top期刊),  IF=4.946  通讯作者 20160301

(26) Yaqin Xu, Fei Cai, Zeyuan Yu, Ling Zhang, Xingguo Li, Yu Yang*, Gaijie Liu. Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity. Food Chemistry, 2016, 194: 650-658. (SCI, 中科院大类一区, Top, IF=8.8).

(27) Yu Yang, Xuhong Yuan, Yaqin Xu, Zeyuan Yu. Purification of anthocyanins from extracts of red raspberry using macroporous resin. International Journal of Food Properties, 2015, 18:1046-105. 中科院四区 IF=1.845

(28) 徐雅琴, 邵春天, 耿 莹, 郑秀雯, 王茹娟, 杨昱*, 蓝靛果硒多糖的理化性质、结构表征及红细胞氧化损伤保护活性. 食品化学, 2023, 44(6): 17-24. (EI).

(29) 徐雅琴, 杨海红, 李大龙, 陈哲, 王丽波, 杨昱*, 黑加仑果实降解多糖理化特性、结构及体外降血糖活性, 食品化学, 2021 2021,42(15), 37-43. (EI).

(30) 徐雅琴, 付雪婷, 王丽波, 刘博, 车发, 杨昱*, 乙酰化修饰对黑穗醋栗果实多糖结构特性及活性的影响, 精细化工, 2019, 12: 2467-2475. (EI).

(31) 杨昱,雷泽夏,白靖文,王中江,齐宝坤,江连洲. 极端pH 处理对大豆分离蛋白、β-伴大豆球蛋白、大豆球蛋白结构和功能特性的影响, 中国食品学报, 2018, 18(7): 306-313.(EI)

(32) 于泽源, 赵剑辉, 李兴国, 徐雅琴, 汤雪,杨昱*. 大孔树脂-中压柱层析法联用分离纯化蓝莓花色苷研究, 食品科学, 2018, 39(1): 118-123. (EI). 

(33) 徐雅琴, 刘菲, 郭莹莹, 陈宏超, 王丽波, 杨昱*.黑穗醋栗果实超声波降解多糖的结构及抗糖基化活性, 农业工程学报, 2017, 33(5): 295-300. (EI).

(34) 徐雅琴, 蔡菲,王丽波, 倪耀成, 杨昱*. 双水相法分离黑穗醋栗果实多糖及结构和活性的研究, 中国食品学报, 2017, 17(1), 100-107. (EI). 

(35) 杨昱,徐雅琴,于泽源.树莓叶片黄酮成分分离纯化研究[J]. 高校化学工程学报,2011,25(6):948-954. (EI收录).

近五年授权的专利等情况

[1] 和厚朴酚在抑制猪链球菌或其生物被膜中的用途, 授权号:ZL202010137016.2, 授权公告日:2023年08月18日,申请日:2020-03-02.

[2] 一种同时制备黑穗醋栗多酚及多糖的方法, 授权专利号:ZL202010231659.3, 授权公告日:2022.01.18,申请日:2020-03-27.

[3] 一种北五味子果实中活性成分集成提取的方法,授权专利号:ZL202111180006.8,2022.12.23授权,申请日:2021-10-11.

[4] 一种羧甲基蒲公英多糖的制备方法和应用,授权专利号:ZL 202111209092.0, 2023.5.16授权,申请日:2021-10-18

[5] 一种大豆分离蛋白水解物-五味子多糖运载槲皮素的抗菌乳液制备方法,申请号:CN202311286162.1,申请日:2023年10月8日.

[6] 一种集成共提平贝生物碱及多糖的方法,申请号:CN202311206472.8,申请日:2023年09月18日.

[7] 一种温度响应型深共晶双水相体系同时提取北五味子多糖和多酚的方法,申请号:CN202311094637.7,申请日:2023年08月29日.

[8] 一种固定化酶联合高压提取刺五加苷B的方法,CN202211348217.2,申请日:2022年12月13日.

[9] 一种静态高压联合果胶酶降解黑穗醋栗多糖的方法,CN202211601202.2,申请日:2022年10月31日.

[10] 一种北五味子果实中多糖的提取方法,CN202310705026.5,申请日:2023年06月14日.

[11] 一种共载巴西苏木素和链霉素协同抗菌脂质体的制备方法及应用,CN202311134797.X, 申请日:2023年09月04日.

其他获奖及荣誉称号

[1] 国家自然科学基金、黑龙江/广东/广西/四川省自然科学基金评审专家;

[2] 东北农业大学杰出学者JC2,2022年;

[3] 东北农业大学优秀共产党员,东北农业大学,2020年;

[4] 东北农业大学教书育人先进个人,东北农业大学,2015年;

[5] 东北农业大学巾帼女杰,东北农业大学,2016年;

[6] 第二届全国高校微课教学比赛二等奖,第一名,2015年;

[7] 黑龙江省第三届教师技能大赛二等奖,第一名,2015年 

[8] 东北农业大学第三届课堂教学质量奖一等奖,第一名,2020年

[9] 黑龙江省第二届高等学校微课比赛一等奖,第一名,2014年

[10] 东北农业大学教师技能大赛一等奖,第一名,2015年

[11] 东北农业大学微课大赛一等奖,第一名,2014年

[12] 东北农业大学优秀教案评比一等奖,2021.