课程编号 | 课程名称 | 课程级别 | 学时 |
1. “新型生物农药分子创制与产业化”国家重点研发计划项目(2023YFD1700700),2023.12-2027.12,主持人
2. “促进寒地水稻直播发芽出苗有益微生物和活性化合物研究”黑龙江自然科学基金研究团队项目(TD2022C002),2023.01-2026.12,主持人
2. “有害生物侵染作物后招募防御微生物的发掘与应用基础研究”国家自然科学基金重点项目(32030090),2021.01-2025.12,主持人
3. “新型植物生长调节剂五谷丰素早期应答基因及调控代谢通路研究”国家自然科学基金面上项目(31872037),2019.01-2022.12,主持人
4. “S. avermitilis neau1069全基因组鉴定代谢杀虫剂多拉菌素调控基因及调控机理研究”国家自然科学基金面上项目(31672092),2017.01-2020.12,主持人
5. “微生物天然产物农药创制创新团队”农业部农业科研杰出人才及创新团队,2015年
6. 长江学者(特聘教授),2014年
7. “大豆根内特异微生物及疫霉病菌侵染后根招募微生物代谢活性化合物研究”国家自然科学基金面上项目(31471832),2015.01-2018.12,主持人
8. “微生物天然产物农药”国家自然科学杰出青年基金(31225024),2013.01-2016.12,主持人
9. 国家“万人计划”,科技部“中青年科技创新领军人才”,2012年
10. “Streptomyces avermitilis neau1069生物合成多拉菌素(Doramectin)基因簇克隆和关键基因功能分析”国家自然科学基金面上项目(31071750),2011.01-2013.12,主持人
1. 农用抗生素高效发现新技术及系列新产品产业化,中华人民共和国国务院,国家科技发明奖,二等奖(排名第1),2015年。
2. 链霉菌天然产物农药代谢机制认知和高效生物制造,黑龙江省科学技术厅,科技发明一等奖(排名第1),2021年。
3. 重要功能农业微生物资源研究及产业化应用,黑龙江省科学技术厅,科技发明一等奖(排名第1),2018年。
4. 高效筛选农用抗生素体系构建及产多拉菌素新菌株发现与产业化,黑龙江省科学技术厅,科技发明一等奖(排名第1),2014年。
5. 农用抗生素米尔贝霉素、米尔贝肟原料药研制及产业化,黑龙江省科学技术厅,科技发明一等奖(排名第1),2011年。
1.
Wei-shan Wang , Shan-shan Li , Zi-long Li, Jing-yu Zhang, Ke-qiang Fan, Gao-yi Tan , Guo-min Ai, Sin-Man Lam,
Guang-hou Shui, Zhi-heng Yang, Hong-zhong Lu, Pin-jiao Jin, Yi-hong Li, Xiang-yin
Chen, Xue-kui Xia, Xue-ting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang , Si-liang Zhang, Gil
Alterovitz, Wen-sheng Xiang*,Li-xin Zhang*. Harnessing the
intracellular triacylglycerols for titer improvement of polyketides in
Streptomyces. Nat Biotechnol. 2020,38(1). IF=68.164 生物 一区Top
2.
Zhi-yin
Yu, Jian-Ping
Huang, Jing Yang, Chong-xi
Liu, Yi-jun Yan, Li
Wang, Jun-wei
Zhao, Yin Chen, Wen-sheng
Xiang*, Sheng-Xiong Huang*, Discovery
and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors.
Nat. Commun. 2023, DOI:10.1038/s41467-023-35829-1. IF=17.694, 综合性期刊 一区Top
3.
Chong-xi Liu, Zhi-yan Wang, Yin Chen, Yi-jun Yan, Lei Li,
Yong-Jiang Wang, Lu Bai, Shan-shan Li, Yan-yan Zhang, Xiang-jing Wang, Sheng-xiong
Huang*, Wen-sheng Xiang*. Guvermectin Biosynthesis Revealing the Key
Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate
of a Noncanonical Adenine Phosphoribosyltransferase. ACS Chemical Biology.
2023, DOI:10.1021/acschembio.2c00739. IF=4.634, 生物 二区
4.
Chong-xi Liu, Lu Bai, Peng Cao, Shan-shan Li, Sheng-xiong
Huang, Ji-dong Wang, Lei Li, Ji Zhang, Jun-wei Zhao, Jia Song, Peng Sun,
Yan-yan Zhang, Hui Zhang, Xiao-wei Guo, Xi-lang Yang, Xin-qiu Tan, Wen-de Liu,
Wang, Xiang-jing Xiang*, Wen-sheng Xiang*. Novel Plant Growth Regulator
Guvermectin from Plant Growth- Rhizobacteria Boosts Biomass and Grain Yield in
Rice. J. Agric. Food Chem. 2022, DOI:10.1021/acs.jafc.2c07072. IF=5.895 农林科学 一区
5.
Chuan-yu Han#, Zhi-yin Yu#, Yu-ting Zhang, Zhi-yan Wang, Jun-wei
Zhao, Sheng-Xiong Huang, Zhong-hua Ma, Zi-yue Wen, Chong-xi Liu*, Wen-sheng
Xiang*. Discovery of Frenolicin B as Potential Agrochemical Fungicide for
Controlling Fusarium Head Blight on Wheat. J. Agric. Food Chem. 2021: 69 (7). IF=5.895 农林科学 一区
6.
Yu-qing Liu, Hai-yan Wang, Shan-shan Li, Yan-yan Zhang, Xu
Cheng, Wen-sheng Xiang*, Xiang-jing Wang*. Engineering of primary
metabolic pathways for titer improvement of milbemycins in Streptomyces
bingchenggensis. Appl Microbiol Biotechnol. 2021 Mar; 105 (5). IF=5.56 工程技术 二区
7.
Li-yang Chu#, Shan-shan Li#, Zhuo-xu Dong, Yan-yan Zhang, Pin-jiao
Jin, Lan Ye, Xiang-jing Wang*,Wen-sheng Xiang*. Mining and engineering exporters for titer
improvement of macrolide biopesticides in Streptomyces. Microb Biotechnol. 2021
Aug; 15 (4). IF=6.575 生物 二区
8.
Xiao-yan Yu, Jing Zhang, Xue Zhang, Xi-lang Yang, Xi Xu, Jia-ying
Lin, Hui Bing, Xiang-jing Wang, Jun-wei Zhao*, Wen-sheng Xiang*.
Identification and Pathogenicity of Fungi Associated with Leaf Spot of
Muskmelon in Eastern Shandong Province. China. Plant Dis. 2021 Oct 13. IF=4.614
农林科学 二区
9.
Xi Xu#, Li Zhang#, Xi-lang Yang, Han-shui Cao, Jing-jing Li,
Peng Cao, Li-feng Guo, Xiang-jing Wang, Jun-wei Zhao*, Wen-sheng Xiang*.
Alternaria spp. associated with leaf blight of maize in Heilongjiang Province,
China. Plant Dis, 2021 Sep 02. IF=4.614 农林科学 二区
10.
Zhi-yin Yu, Hao Jiang, Li Wang, Feng-Xian Yang, Jian-Ping
Huang, Chong-xi Liu, Xiao-wei Guo, Wen-sheng Xiang*, ShengXiong Huang*.
Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99. Front
Chem. 2020 Feb 18;8:95. IF=5.545 化学 二区
11.
Hai-yan Wang, Xu Cheng, Yu-qing Liu, Shan-shan Li, Yan-yan
Zhang, Xiang-jing Wang*, Wen-sheng Xiang*. Improved milbemycin
production by engineering two Cytochromes P450 in Streptomyces bingchenggensis.
Appl Microbiol Biotechnol. 2020 Apr;104(7). IF=5.56 工程技术 二区
12.
Pin-jiao Jin, Shan-shan Li, Yan-yan Zhang, Li-yang Chua, Hai-rong
He, Zhuo-xu Dong, Wen-sheng Xiang*. Mining and fine-tuning sugar uptake
system for titer improvement of milbemycins in Streptomyces bingchenggensis.
Synth Syst Biotechnol. 2020 Jul 14;5(3). IF=4.692 生物 二区
13.
Hui Liu, Yan-yan Zhang, Shan-shan Li, Jia-bin Wang, Xiang-jing
Wang*, Wen-sheng Xiang*. Elucidation of the Activation Pathways of
ScyA1/ScyR1, an Aco/ArpA-Like System That Regulates the Expression of
Nemadectin and Other Secondary Metabolic Biosynthetic Genes. Front Bioeng
Biotechnol. 2020 Nov 3;8. IF=6.064 工程技术 二区
14.
Xiao-wei Guo, Ji-dong Wang, Can Su, Chong-xi Liu, Xiao-yan
Ma, Zhi-yin Yu, Jian-song Li, Xiang-jing Wang, Wen-sheng Xiang*, Sheng
Xiong Huang*. unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic
virus from Streptomyces gamaensis. Organic Chemistry Frontiers. 2019(6)18.
IF=5.281 化学 一区
15.
Yue-ming Shan, Chang-long Shu, Kang-lai He, Xue Cheng, Li-li
Geng, Wen-sheng Xiang*, and Jie Zhang*. Characterization of a novel
insecticidal protein Cry9Cb1 from Bacillus thuringiensis. J Agric Food Chem.
2019 ,67(13). IF=5.895 农林科学 一区
16.
Chuang Li, Hai-rong He, Jia-bin Wang, Hui Liu, Hai-yan Wang,
Ya-jie Zhu, Xiang-jing Wang, Yan-yan Zhang*, Wen-sheng Xiang*.
Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and
its application for increasing nemadectin production in Streptomyces
cyaneogriseus. SCIENCE CHINA (Life Sciences), 2019,62 (3). IF=10.384 生物 一区
17.
Hai-rong He, Lan Ye, Chuang Li, Hai-yan Wang, Xiao-wei Guo,
Xiang-jing Wang, Yan-yan Zhang*, Wen-sheng Xiang*. SbbR/SbbA, an
Important ArpA/AfsA-Like System, Regulates Milbemycin Production in
Streptomyces bingchenggensis. Front Microbiol. 2018 May 23;9. IF=6.064 生物 二区
18.
Wei Song, Li-ping Duan, Jun-wei Zhao, Shan-wen Jiang, Xiao-wei
Guo, Wen-sheng Xiang*, Xiang-jing Wang*. Kribbella monticola sp. nov., a
novel actinomycete isolated from soil. Int J Syst Evol Microbiol. 2018
Nov;68(11). IF=2.689 生物 三区
19.
Dong-mei Li, Hao Jiang, Li-yuan Han, Yuan-yuan Li, Jun-wei
Zhao, Shan-wen Jiang, Xiang-jing Wang*, Wen-sheng Xiang*. Lentzea terrae sp.
nov., isolated from soil and an emended description of Lentzea soli. Int J Syst
Evol Microbiol. 2018, 68(11). IF=2.689 生物 三区
20.
Yuan-yuan Tian, Chuan-yu Han, Jun-wei Zhao, Hao-ran Shi,
Jiang-mei-hui Hu, Shan-wen Jiang, Xiao-yang Han, Xiang-jing Wang*, Wen-sheng
Xiang*. Streptomyces triticisoli sp. nov., a novel actinomycete isolated
from rhizosphere soil of wheat (Triticum aestivum L.). Int J Syst Evol
Microbiol. 2018,68(10). IF=2.689 生物 三区
1.
授权发明专利:“一种以谷维菌素为有效成分的植物生长调节剂“(排名第1),2022年,中国,ZL 201910189087.4
2.
授权发明专利:“一株链霉菌及其应用“(排名第1),2022年,中国,ZL 201910189570.2
3.
授权发明专利:“福临霉素在抑制引起植物病害的病原真菌活性中的应用“(排名第1),2021年,中国,ZL202010026658.5
4.
授权发明专利:“一种生物碱类化合物及其制备方法和应用“(排名第1),2021年,中国,ZL 201910501587.7
5.
授权发明专利:“一种大环内酯类化合物及其制备方法和应用“(排名第1),2015年,中国,ZL 2013101623698.8
6.
授权发明专利:“勃利霉素对大豆疫霉根腐病的防治作用“(排名第1),2015年,中国,ZL 201180069377.7
7.
授权发明专利:“一种冰城链霉菌的基因阻断突变菌及其制备方法和应用“(排名第1),2015年,中国,ZL 201310409240.2
国家杰出青年基金获得者
“长江学者”特聘教授
国家“万人计划”、科技部“中青年科技创新领军人才”
国家“百千万人才工程”有突出贡献中青年专家
农业部农业科研杰出人才及创新团队
教育部新世纪优秀人才
全国先进工作者
全国模范教师
全国优秀科技工作者
黑龙江省“龙江学者特聘教授”
黑龙江省杰出青年基金
黑龙江省五一劳动奖获得者
黑龙江省“十佳最美”教师
黑龙江省高校“三育人”优秀教师