姓名:刘芳萍
性别:女
出生年月:1973-09-22
职称:教授
办公电话:14745170578
工作单位:动物医学学院
E-mail:liufangping@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
106121 兽医药理学研究进展 博士课 48
106234 分子药理学 博士课 32
106214 毒理学研究进展 博士课 32
206308 兽医药代动力学 硕士课 48
206364 抗菌药物专题 硕士课 48
306316 兽医药理学专题与案例分析 硕士课 32
近五年主持科研项目概况

1. 《二氢杨梅素调控NLRP3炎症小体的靶标确证及干预内毒素致鸡细胞焦亡的机制研究》,国家自然科学基金项目,2024-2027

2. 《实验羊驼生物学数据的测定及在新兽药研发中的初步应用研究》,“十四五”国家重点研发计划项目子课题,2022-2026

3. 《建立SPF猪生物学特性描述规范和数据库》,“十三五”国家重点研发计划课题子课题,2017-2020

4.HNF-1调节GSTA1表达的机制及与JNK细胞信号通路关系研究》,国家自然科学基金项目,2015-2018


近五年项目获奖概况
近五年代表性著作、论文

1Lina JiaYingchao GongXinru JiangXianan FanZhenghua JiTianwen MaRui LiFangping Liu*Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritisJOURNAL OF ETHNOPHARMACOLOGY, 2024, 325: 117887.

2Chenxi Shi , Jiaqi Wang , Ruichen Zhang , Muhammad Ishfaq , Ying Li , Ruihui Zhang , Chuanbiao Si , Rui Li, Changwen Li and Fangping Liu*. Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 infammasomeVETERINARY RESEARCH, 2022, 531:61-16.

3Yuanyuan Zhang, Bingke Ma, Shuangshuang Hao, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Chenxi Shi, Liang Yuan, Rui Li, Changwen Li, Fangping Liu*. Drug-induced liver injuryOltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway, Journal of Applied Toxicology2021, 41(12): 2011-2020.

4Yicong Chang, Jingshan He, Bingke Ma, Muhammad Ishfaq, Jiaqi Wang, Ruichen Zhang, Liang Yuan, Jiarui Liu, Changwen Li, Fangping Liu*. Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement,  Molecular & Cellular Toxicology, 2021,17(2): 161-168.

5Changwen Li, Feng Wang, Rui Li, Muhammad Ishfaq, Hongyan Chen, Fangping Liu*, Yun Liu*.  Hematologic and biochemical reference intervals for 1-month-old specific-pathogen- free Landrace pigs Veterinary Clinical Pathology2021, 50(1): 76-80.

6Yicong Chang , Liang Yuan , Jiarui Liu, Ishfaq Muhammad , Chuanbao Cao, Chenxi Shi , Yuanyuan Zhang , Rui Li, Changwen Li and Fangping Liu*.  Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 infammasome and TLR4/NF-κB signalling pathway, VETERINARY RESEARCH, 2020511:72 , 1-12.

7Chenxi Shi, Beili Hao, Yang Yang, Ishfaq Muhammad, Yuanyuan Zhang, Yicong Chang, Ying Li, Changwen Li, Rui Li, Fangping Liu*JNK signaling pathway mediates acetaminophen-induced hepatotoxicity accompanied by changes of glutathione S-transferase A1 content and expression, FRONTIERS IN PHARMACOLOGY, 2019, Volume 10, Article 1092.

8Yicong Chang, Feng Wang, Yang Yang, Yuanyuan Zhang, Ishfaq Muhammad, Rui Li, Changwen Li, Ying Li, Chenxi Shi, Xin Ma, Beili Hao, Fangping Liu*. Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, HNF-1 and GSTA1 changesJournal of Applied Toxicology2019, 39(12): 1640-1650.

9Ying Li, Beili Hao, Ishfaq Muhammad, Yuanyuan Zhang, Yang Yang, Chenxi Shi, Yicong Chang, Rui Li, Changwen Li and Fangping Liu*. Acetaminophen-induced reduction in glutathione-S-transferase A1 in hepatocytes: A role for hepatic nuclear factor 1α and its response elementBiochemical and Biophysical Research Communications, 2019516:251-257.

10Rui Li, Feng Wang, Yuanyuan ZhangChangwen LiChangyou XiaHongyan ChenXiaoye Lu, Fangping Liu*. Comparison of hematologic and biochemical reference values in specific-pathogen-free 1-month-old Yorkshire pigs and Yorkshire-Landrace crossbred pigsCanadian Journal of Veterinary Research, 2019,83(4):285-290.

11Chenxi Shi, Minmin Li, Ishfaq Muhammad, Xin Ma, Yicong Chang, Rui Li, Changwen Li, Jingshan He and Fangping Liu*. Combination of berberine and ciprofloxacin reduces multi-resistant Salmonella strain biofilm formation by depressing mRNA expressions of luxS, rpoE, and ompR, JOURNAL OF VETERINARY SCIENCE, 2018. 19(6): 808-816.

12Xin Ma , Yicong Chang, Ishfaq Muhammad, Chenxi Shi , Rui Li , Changwen Li, Zhi Li , Yuexia Lin , Qing Han  and Fangping Liu*. Effects of C2-ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-transferase A1 in Acetaminophen-mediated Acute Mice Liver Injury, frontiers in Pharmacology, 2018, Volume 9, Article 1009.

13Ying Li, Zhi Li, Changwen Li, Xin Ma, Yicong Chang, Chenxi Shi, Jingshan He, Rui Li, Ishfaq Muhammad , Fangping Liu*. Evaluation of hepatoprotective activity of Syringa oblata leaves ethanol extract with the indicator of glutathione S-transferase A1, Revista Brasileira de Farmacognosia, 2018, 28(4): 489-494.

14刘芳萍副主编。《兽医药理学》(第二版),国家林业和草原局普通高等教育十三五规划教材,中国林业出版社,2021.8.

15刘芳萍副主编。《兽医药物分析》(第二版),普通高等教育农业部十二五规划教材,中国农业出版社,2018.4.

16刘芳萍参译,《禽病学》(第十四版),辽宁科学技术出版社,2022.5.


近五年授权的专利等情况
其他获奖及荣誉称号

获黑龙江省畜牧科技奖一等奖1项、黑龙江省教委科技进步三等奖1项、国家发明专利1项。现任农业农村部兽药评审专家,国家自然科学基金评议专家,国家科技专家库专家,中国畜牧兽医学会兽医药理学与毒理学分会常务理事,黑龙江省畜牧兽医学会理事,黑龙江省生理科学会理事等。