姓名:翁晓刚
性别:男
出生年月:1986-10-29
职称:副研究员
办公电话:
工作单位:生命科学学院
E-mail:wengxg@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
09600077x 实验动物学 本科 24
09600074z 动物胚胎工程 本科 32
309324 胚胎工程在育种及生物医药中的应用 硕士 32
近五年主持科研项目概况

(1) 猪体外胚胎工程化发育技术体系的建立2022.12-2027.11国家重点研发计划项目子课题,100万元,主持

(2) 猪体细胞核移植胚胎X染色体活性变化及其调控机制探索,2021.1-2024.12国家自然科学基金面上项目,58万元,主持;

(3) H3K9me3H3K27me3对猪体细胞重编程影响机制,2017.1-2019.12国家自然科学基金青年基金项目,19万元,主持;

(4) 质膜脂质组成对猪精子耐冻性的影响及其机制探究,省优青项目,2023.7-2026.710万元,主持;

(5) 猪体细胞核移植胚胎H3K27me3异常重编程机制,省基金面上项目,2017.10-2020.106万元,主持;

(6) 猪克隆胚胎发育过程中H3K27me3依赖印记基因挖掘及其功能研究,省博士后科研启动金项目,2021.11-2024.1110万元,主持;

(7) 基于多基因编辑的糖尿病模型猪创制与表型评价,横向课题,2023.4-2026.450万元,主持;

(8) 猪初始态(naive)多能干细胞系建立及多能性调控机制解析,2016.1-2020.122833万元,参与。


近五年项目获奖概况

早期胚胎分化与多能性分子调控机制,2021年度黑龙江省高校科学技术一等奖,第四名。


近五年代表性著作、论文

(1)  Zhang YT#, Yuan WJ#, Liu YC, Liu Y, Liang HL, Xu QQ, Liu ZH*, Weng XG*. Plasma membrane lipid composition and metabolomics analysis of Yorkshire boar sperms with high and low resistance to cryopreservation. Theriogenology. 2023; 206:28-39.

(2)  An JM, Weng XG*, Collectively encoding protein properties enriches protein language models. BMC Bioinformatics. 2022; 23:467.

(3)  Weng XG#, Cai MM#, Zhang YT, Liu Y, Liu C, Liu ZH*. Improvement in the in vitro development of cloned pig embryos after kdm4a overexpression and an H3K9me3 methyltransferase inhibitor treatment. Theriogenology. 2020; 146:162-170.

(4)  Weng XG#, Cai MM#, Zhang YT, Liu Y, Gao ZL, Song J, Liu ZH*. Effect of Astragalus polysaccharide addition to thawed boar sperm on in vitro fertilization and embryo development. Theriogenology. 2018; 121:21-26.

(5)  Weng XG#, Liu Y#, Zhou SH, Zhang YT, Shao YT, Xu QQ, Liu ZH*. Evaluation of porcine circovirus type 2 infection in in vitro embryo production using naturally infected oocytes. Theriogenology. 2019; 126:75-80.

(6)  Zhang YT, Liu Y, Liang HL, Xu QQ, Liu ZH*, Weng XG*. Metabolomic differences of seminal plasma between boars with high and low average conception rates after artificial insemination. Reproduction in Domestic Animals. 2021; 56:161-171.

(7)  Zhang YT, Yao W, Chai MJ, Liu WJ, Liu Y, Liu ZH*, Weng XG*. Evaluation of porcine urine-derived cells as nuclei donor for somatic cell nuclear transfer. Journal of Veterinary Science. 2022, 23:40-53.

(8)  Zhang YT, Liang HL, Liu Y, Zhao M, Xu QQ, Liu ZH*, Weng XG*: Metabolomic Analysis and Identification of Sperm Freezability-Related Metabolites in Boar Seminal Plasma. Animals. 2021; 11:1939.

(9)  Xie BT, Zhang H, Wei RY, Li QN, Weng XG, Kong QR, Liu ZH. Histone H3 lysine 27 trimethylation acts as an epigenetic barrier in porcine nuclear reprogramming. Reproduction. 2016; 151:9-16.

(10)  Bou G, Liu SC, Sun MJ, Zhu J, Xue BH, Guo J, Zhao YM, Qu B, Weng XG, Wei YC. CDX2 is essential for cell proliferation and polarity in porcine blastocysts. Development. 2017; 144:1296-1306.

(11)  Liu SC, Bou GC, Zhao JC, Guo SM, Guo J, Weng XG, Yin Z, Liu ZH. Asynchronous CDX2 expression and polarization of porcine trophoblast cells reflects a species‐specific trophoderm lineage determination progress model. Molecular Reproduction and Development. 2018; 85:590-598.

(12)  Kong QR, Yang X, Zhang H, Liu SC, Zhao JC, Zhang JM, Weng XG, Jin JX, Liu ZH. Lineage specification and pluripotency revealed by transcriptome analysis from oocyte to blastocyst in pig. The FASEB Journal. 2020; 34:691-705.

(13)  刘雨辰,杨芷珊,张宇霆,刘忠华,翁晓刚*,哺乳动物早期胚胎发育过程中X染色体失活的研究进展,中国细胞生物学学报, 2022, 44(11): 2223-2232.

(14)  袁文静,张宇霆,刘忠华,翁晓刚*,哺乳动物原始生殖细胞中X染色体活性研究进展,中国细胞生物学学报,2023, 45(6): 929935.


近五年授权的专利等情况

(1) 翁晓刚,刘忠华等,一种猪冻精解冻稀释液及其配制方法. 专利授权号:ZL201710802837.1,中国,2018年;

(2) 刘忠华,翁晓刚等,一种诱导后备母猪同期发情的方法. 专利授权号:ZL201810813305.2,中国,2021年。


其他获奖及荣誉称号

荣誉称号

1、黑龙江省优青;

2、黑龙江省高校青年创新人才;

3、东北农业大学“青年才俊”;

4、《中国畜禽种业》青年编委。