课程编号 | 课程名称 | 课程级别 | 学时 |
1. “十四五”国家重点研发计划子课题,2022YFD1800805,表达PEDV保护性抗原重组乳酸菌口服疫苗的研制,2022.11-2025.12,50万元,在研,主持
2. 国家自然科学基金青年基金,31702260,TGEV Nsp2诱导宿主炎症防疫的机制及其与病毒致病性的关系,2018.1-
2020.12,25万元,已结题,主持
3. “十二五”农村领域国家科技计划,2015BAD12B02-7,猪病毒性腹泻的重组乳酸杆菌活载体疫苗研制与开发,2015.4-2019.12,90万元,已结题,主持
4. 中国博士后科学基金面上项目,2016M601408,猪传染性胃肠炎病毒致炎相关蛋白与其致病性关系的研究,2016.11-2019.11,5万元,已结题,主持
5. 黑龙江省科技创新人才项目,UNPYSCT-2018147,猪传染性胃肠炎病毒非结构蛋白与其致病性的关系,2018.8- 2021.9,10万元,已结题,主持
6. 国家疫病病原生物学国家重点实验室开放基金课题,SKLVEB2018KEKT004,PEDV、TGEV和PoRV的重组乳酸杆菌活载体三联疫苗的研制,2018.12-2020.11,10万元,已结题,主持
7. 东北农业大学“学术骨干”项目,TGEV感染诱导宿主细胞凋亡的机制,2020.1-2022.12,10万元,已结题,主持
8. 东北农业大学“青年才俊”项目,16QC24,调控NF-κB信号通路的猪传染性胃肠炎病毒蛋白的筛选及其作用机制,2016.6-2018.6,6万元,已结题,主持
1. 基因工程乳素菌微生态制剂的分子设计及机制研究,黑龙江省畜牧科技奖,一等奖,第3名,2018
1. Wang Y, Sun A, Sun Y, Zhang S, Xia T, Guo T, Hao Z, Sun L, JiangY, Qiao X, Cui W, Tang L, Xu Y, Li Y, Wang L*. Porcine transmissible gastroenteritis virus inhibits NF-kB activity via nonstructural protein 3 to evade host immunesystem.Virology Journal.2019,16:97-109.
2. Wang L, Zhao D, Sun B,Yu M, Wang Y, Ru
Y, Jiang Y, Qiao X, Cui W,Zhou H, LiY, XuY,Tang L. Oral vaccination with the
porcine circovirus type 2 (PCV-2) capsid protein expressed by Lactococcus
lactis induces a specific immune response against PCV-2 in mice. Journal of
Applied Microbiology. 2019,128(1):74-87.
3.
4. Wang L, Qiao X, Zhang S, Qin Y, Guo T,
Hao Z, Sun L, Wang X, Wang Y, Jiang Y, Tang L, Xu Y, Li Y. Porcine
transmissible gastroenteritis virus nonstructural protein 2 contributes to
inflammation via NF-κB activation,Virulence.2018,9(1):1685-1698.
5. Ma S#, Wang L#, Huang X, Wang X, Chen S, Shi W, Qiao X, Jiang Y, Tang L, Xu Y, Li
Y. Oral recombinant Lactobacillus vaccine targeting the intestinal microfold
cells and dendritic cells for delivering the core neutralizing epitope of
porcine epidemic diarrhea virus. Microb CellFact. 2018,9:17(1):20.
6. WuY#, Wang L#, GuoT, JiangY, Qiao X, Sun L, Liu M, Tang L, XuY, LiY.
Identification of amino acid residues in infectious hematopoietic necrosis
virus (IHNV) NV protein necessary for viral replication and pathogenicity.Fish
Shellfish Immunol.2018,79:294-302.
7. Wang XN#, Wang L#, Zheng DZ, Chen S, Shi W, Qiao XY, Jiang YP, Tang LJ, Xu YG, Li YJ.
Oral immunization with a Lactobacillus casei-based antiporcine epidemic
diarrhoea virus (PEDV) vaccine expressing microfold cell-targeting peptide Co1
fused with the COE antigen of PEDV. Journal of Applied Microbiology.J Appl
Microbiol. 2018,124(2):368-378.
8. Wang X#, Wang L#, Huang X, Ma S, Yu M, Shi W, Qiao X, Tang L, Xu Y, Li Y. Oral
Delivery of Probiotics Expressing Dendritic Cell-Targeting Peptide Fused with
Porcine Epidemic Diarrhea Virus COE Antigen:A Promising Vaccine Strategy
against PEDV.Viruses. 2017,9(11):E312.
9. MeilingYu#, Li
Wang#, Sunting Ma , Xiaona Wang ,Yusai Wang ,Ya
Xiao,Yanping Jiang, Xinyuan Qiao, Lijie Tang, Yigang Xu*, Yijing Li*.
Immunogenicity of eGFP-marked recombinant Lactobacillus casei against
transmissible gastroenteritis virus and porcine epidemic diarrhea virus.
Viruses. 2017,9:274.
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