主持国自然面上和青年项目、国家重点研发计划子项目、省杰出和优秀青年科学基金、省重点研发计划项目、教育部博士点基金、中国和黑龙江省博士后特别和一等资助等课题20项。

围绕“人兽共患原虫适应性寄生机制”展开研究，第一/通讯作者SCI工作45篇，其中国际合作15篇，4篇为ESI热点/高他引论文（2019/2015/2021/2024年发表的论文被引273/145/89/18次），被CID、EID等顶刊论文引用2000次，>95%他引，>35%引自国外。论文发表在Cell子刊Trends Parasitol、美国微生物学会经典期刊J Clin Microbiol和Appl Environ Microbiol、PLoS经典期刊PLoS Negl Trop Dis、寄生虫学经典期刊Int J Parasitol等。获授权发明专利5项，省市科技进步二等奖各1项。

人兽共患肠道原虫免疫适应性机制方向

1. Yu X, Yang Y, Zhu W, Liu M, Wu J, Singer S. M., Li W*. 2024 The pathogenic responses elicited during exposure of human intestinal cell line with Giardia duodenalis excretory-secretory products and the potential attributed endocytosis mechanism. Med Microbiol Immunol 213:23.

2. Zhao Y, Yang Y, Liu M, Qin X, Yu X, Zhao H, Li X, Li W*. 2022. COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis. PLoS Negl Trop Dis 16:e0010402.

3. Yang Y, Zhao Y, Liu L, Zhu W, Jia S, Li X, Li W*. 2022. The anti-apoptotic role of COX-2 during in vitro infection of human intestinal cell line by Giardia duodenalis and the potential regulators. Infect Immun 90:e0067221.

人兽共患肠道原虫遗传适应性机制方向

1. Li W, Feng Y, Santin M*. 2019. Host specificity of Enterocytozoon bieneusi and public health implications. Trends Parasitol 35:436-451.

2. Li W, Feng Y*, Xiao L*. 2022. Enterocytozoon bieneusi. Trends Parasitol 38:95-96.

3. Li W*, Xiao L*. 2021. Ecological and public health significance of Enterocytozoon bieneusi. One Health 12:100209.

4. Wan Q, Xiao L, Zhang X, Li Y, Lu Y, Song M, Li W*. 2016. Clonal evolution of Enterocytozoon bieneusi populations in swine and genetic differentiation in subpopulations between isolates from swine and humans. PLoS Negl Trop Dis 10:e0004966.

5. Yang J, Song M, Wan Q, Li Y, Lu Y, Jiang Y, Tao W, Li W*. 2014. Enterocytozoon bieneusi genotypes in children in northeast China and assessment of risk of zoonotic transmission. J Clin Microbiol 52:4363-7.

6. Li W, Kiulia NM, Mwenda JM, Nyachieo A, Taylor MB, Zhang X, Xiao L*. 2011. Cyclospora papionis, Cryptosporidium hominis, and human-pathogenic Enterocytozoon bieneusi in captive baboons in Kenya. J Clin Microbiol 49:4326-9.

7. Jiang Y, Tao W, Wan Q, Li Q, Yang Y, Lin Y, Zhang S, Li W*. 2015. Zoonotic and potentially host-adapted Enterocytozoon bieneusi genotypes in sheep and cattle in northeast China and an increasing concern about the zoonotic importance of previously considered ruminant-adapted genotypes. Appl Environ Microbiol 81:3326-35.

8. Li W, Cama V, Feng Y, Gilman RH, Bern C, Zhang X, Xiao L*. 2012. Population genetic analysis of Enterocytozoon bieneusi in humans. Int J Parasitol 42:287-93.

9. Jiang S, Yu S, Feng Y, Zhang L, Santin M, Xiao L*, Li W*. 2024. Widespread distribution of human-infective Enterocytozoon bieneusi genotypes in small rodents in northeast China and phylogeny and zoonotic implications revisited. Acta Trop 253:107160.

“龙江学者”特聘教授、黑龙江“省杰青”、东北农业大学“学术英才”