发酵床模式下不同品种育肥猪的生产状况评估，2019.8—2020.12.主持

北方阳光大棚养殖模式研发与应用效果研究，2019.11—2022.12.主持

黑龙江省自然科学基金面上项目:

改善妊娠期环境对提高母猪母性能力机制的研究 2016.7-2019.7.主持

农业农村部生猪产业技术体系子课题:

饲养工艺及饲养管理，2017-2021，主持

2023年中国农业国际合作促进会授予“农场动物福利科技人物”奖

Zhou, Sitong, Zhang, Xiaohong, Fu, Qin, Cheng, Zheng, Ji, Wenbo and Liu, Honggui . The use of selenomethionine to reduce ammonia toxicity in porcine spleen by inhibiting endoplasmic reticulum stress and autophagy mediated by oxidative stress [J]. Ecotoxicology and Environmental Safety, 2022, 242: 113887.

Yiming, Zhang, Hang, Yin, Bing, Shao, Hua, Xue, Bo, Huang, Honggui, Liu and Shu, Li. Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen [J]. Ecotoxicology and environmental safety, 2021, 209: 111819.

Yang, Zijiang, Wang, Shengchen, Liu, Honggui and Xu, Shiwen. MAPK/iNOS pathway is involved in swine kidney necrosis caused by cadmium exposure [J]. Environmental Pollution, 2021, 274: 116497.

Xu, Shi, Xiaojing, Li, Xinyue, Sun, Wei, Cui, Honggui, Liu and Shiwen, Xu. Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance [J]. Ecotoxicology and environmental safety, 2021, 225: 112757.

Wang, Huan, Zeng, Xiangyin, Zhang, Xinxin, Liu, Honggui and Xing, Houjuan. Ammonia exposure induces oxidative stress and inflammation by destroying the microtubule structures and the balance of solute carriers in the trachea of pigs [J]. Ecotoxicology and Environmental Safety, 2021, 212: 111974.

Li, Yulong, Zhang, Yue, Feng, Rui, Zheng, Peng, Huang, He, Zhou, Sitong, Ji, Wenbo, Huang, Fushuo, Liu, Honggui and Zhang, Guixue. Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets [J]. Ecotoxicology and Environmental Safety, 2022, 233: 113345.

Cui, Wei, Zhou, Sitong, Wang, YuLin, Shi, Xu and Liu, Honggui. Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue [J]. Ecotoxicology and Environmental Safety, 2021, 228: 113015.

Cheng, Zheng, Shu, Yufu, Li, Xin, Li, Yutao, Zhou, Sitong and Liu, Honggui. Evaluation of potential cardiotoxicity of ammonia: l-selenomethionine inhibits ammonia-induced cardiac autophagy by activating the PI3K/AKT/mTOR signaling pathway [J]. Ecotoxicology and Environmental Safety, 2022, 233: 113304.

Bi, Yanju, Wei, Haidong, Nian, Haoyang, Liu, Runze, Ji, Wenbo, Liu, Honggui and Bao, Jun. Socializing models during lactation alter colonic mucosal gene expression and fecal microbiota of growing piglets [J]. Frontiers in Microbiology, 2022, 13: 819011.

Liu, H., R. Yi, C. Wang, P. Zhao, M. Zhang, S. Xu and J. Bao. Behavior and physiology of two different sow breeds in a farrowing environment during late 35-day lactation [J]. Plos one, 2018, 13(5): e0197152.

Liu, H., R. Yi, Y. Bi, J. Li, X. Li, S. Xu and J. Bao. Physiology, immunity, stereotyped behavior, and production performance of lactating sows in enriched environment [J]. Int J Appl Res Vet Med, 2018, 16: 44-51.

Ji, W., Y. Bi, Z. Cheng, R. Liu, X. Zhang, Y. Shu, X. Li, J. Bao and H. Liu. Impact of early socialization environment on social behavior, physiology and growth performance of weaned piglets [J]. Applied Animal Behaviour Science, 2021, 238: 105314.

Wang, C., Q. Han, R. Liu, W. Ji, Y. Bi, P. Wen, R. Yi, P. Zhao, J. Bao and H. Liu. Equipping farrowing pens with straw improves maternal behavior and physiology of min-pig hybrid sows [J]. Animals, 2020, 10(1): 105.

Ji, W., X. Li, X. Zhang, R. Liu, Y. Shu, Z. Cheng, Y. Bi, H. Liu and J. Bao . Effects of two different early socialization models on social behavior and physiology of suckling piglets [J]. Applied Animal Behaviour Science, 2021, 243: 105436.

Yao, Y., X. Zhao, S. Zheng, S. Wang, H. Liu and S. Xu. Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis [J]. Toxicology, 2021, 461: 152899.

Zhang, H., W. Ji, X. Li, Y. Feng, J. Wang, H. Liu and J. Bao. Immunosuppression, oxidative stress, and apoptosis in pig kidney caused by ammonia: application of transcriptome analysis in risk assessment of ammonia exposure [J]. Toxicology and Applied Pharmacology, 2021, 428: 115675.

Chen, J., B. Shao, J. Wang, Z. Shen, H. Liu and S. Li .Chlorpyrifos caused necroptosis via MAPK/NF-κB/TNF-α pathway in common carp (Cyprinus carpio L.) gills [J]. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2021, 249: 109126.

Zhao, X., S. Wang, X. Li, H. Liu and S. Xu. Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium [J]. Toxicology, 2021, 453: 152733.

Zhao, X., X. Li, S. Wang, Z. Yang, H. Liu and S. Xu. Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation [J]. Journal of Inorganic Biochemistry, 2021, 217: 111361.

Cui, J., H. Liu and S. Xu.Selenium-deficient diet induces necroptosis in the pig brain by activating TNFR1 via mir-29a-3p [J]. Metallomics, 2020, 12(8): 1290-301.

Yang, J., Y. Gong, J. Cai, Y. Zheng, H. Liu and Z. Zhang. Chlorpyrifos induces redox imbalance‐dependent inflammation in common carp lymphocyte through dysfunction of T‐cell receptor γ [J]. Journal of fish diseases, 2020, 43(4): 423-30.

Zhang, Y., J. Cui, Y. Lu, C. Huang, H. Liu and S. Xu. Selenium deficiency induces inflammation via the iNOS/NF-κB pathway in the brain of pigs [J]. Biological trace element research, 2020, 196(1): 103-9.

Cui, Y., K. Yin, Y. Gong, Y. Qu, H. Liu and H. Lin. Atrazine induces necroptosis by miR-181–5p targeting inflammation and glycometabolism in carp lymphocytes [J]. Fish & shellfish immunology, 2019, 94: 730-8.

Yi, R., C. Wang, X. Zhang, P. Zhao, M. Zhang, X. Li, S. Cui, H. Liu and J. Bao. Maternal behavior, posture change, and production performance of lactating sows housed in an enriched environment [J]. Journal of Applied Animal Welfare Science, 2019, 22(3): 298-308.

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(2)   一种母猪产床用教槽料饲喂槽，实用新型，ZL202120147481.4，排名第1；

(3)   一种生猪背膘检测支架，实用新型，ZL201920583319.X，排名第2；

(4)   猪只单体限位栏门闩结构，实用新型，ZL20190575667.2，排名第2；

(5)   一种寒地猪舍通风系统，发明专利，ZL201711130496.4，排名第1；

(6)   一种畜牧粪便样品采集储存装置，发明专利，ZL202110073334.1，排名第3；

(7)   一种便清洁式漏缝地板，发明专利，ZL201910010649.4，排名第2；

(8)   一种酸洗水幕式猪舍内除氨气空气净化装置，发明专利，ZL201911198176.1，排名第3；

(9)   一种猪唾液采集装置，发明专利，ZL202110073347，排名第3。

中国农技协黑龙江亚布力生猪科技小院首席专家

中国农业国际合作促进会动物福利国际合作委员会评审专家

中国畜牧兽医学会家畜环境卫生学研究分会第九届理事会理事

农业农村部生猪养殖设施工程重点实验室主任